Amino Acid Ketoanalogues

Amino Acid Ketoanalogues Uses, Dosage, Side Effects, Food Interaction and all others data.

Each film coated tablet contains- Calcium-3-methyl-2-oxo-valerate (α-ketoanalogue of isoleucine, calcium-salt): 67 mg Calcium-4-methyl-2-oxo-valerate (α-ketoanalogue of leucine, calcium-salt): 101 mg Calcium-2-oxo-3-phenylpropionate (α-ketoanalogue of phenylalanine, calcium-salt): 68 mg Calcium-3-methyl-2-oxobutyrate (α-ketoanalogue of valine, calcium salt): 86 mg Calcium-DL-2-hydroxy-4-(methylthio) butyrate (α-hydroxyanalogue to methionine, calcium-salt): 59 mg L-lysine acetate USP (eqv. to Lysine 75mg) :105 mg L-threonine USP: 53 mg L-tryptophan USP: 23 mg L-histidine USP as Histidine Hydrochloride Monohydrate: 38 mg L-tyrosine USP: 30 mg

Amino Acid Ketoanalogues
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Amino Acid Ketoanalogues
Generic	Amino Acid Ketoanalogues
Type
Therapeutic Class	Other genito-urinary preparations
Manufacturer
Available Country	Bangladesh
Last Updated:	September 24, 2024 at 5:38 am

Uses

Amino Acid Ketoanalogues is indicated for prevention & treatment of damages due to faulty or deficient protein metabolism in chronic kidney disease in connection with a limited dietary protein intake 40 gm/day or less(adult). Usually this applies to patients whose glomerular filtration rate (GFR) is less than 25 ml/min.

Dosage

Amino Acid Ketoanalogues dosage

In general, unless prescribed otherwise, take 4-8 tablets 3 times a day during meals. This dosage applies to adults (with 70 kg body weight). Swallow whole. The tablets must not be chewed. Food should contain 40 g/day protein or less (adults). Ingestion during meals facilitates proper absorption and the metabolisation into the corresponding amino acids. These tablets are given as long as the GFR is between 5 and about 25mL/minute.

Side Effects

Hypercalcaemia (Very Rare), If hypercalcaemia occurs, the intake of vitamin D should be reduced. In case of persisting hypercalcaemia, the dose of Amino Acid Keto Analogues as well as the intake of any other calcium sources has to be reduced.

Precaution

The serum calcium level should be monitored regularly Ensure sufficient calorie intake In the presence of hereditary phenylketonuria, attention should be given to the fact that Amino Acid Keto Analogues contains phenylalanine Monitoring of the serum phosphate levels is needed in case of concomitant administration of aluminium hydroxide

Interaction

Concomitant administration of calcium-containing drugs may cause or aggravate elevated serum calcium levels. In case of aluminum hydroxide administration, the dose of this drug has to be reduced if necessary. Drugs that form hardly soluble compounds with calcium (e.g., tetracyclines, quinolones such as ciprofloxacin and norfloxacin as well as drugs containing iron, fluoride or estramustine) should not be taken at the same time with Amino acid keto analogue to avoid disturbed absorption of the active substance. An interval of at least two hours should elapse between the ingestion of Alpha ketoanalogue and these drugs. The susceptibility to cardioactive glycosides, and hence the risk for arrhythmia will increase in Alpha ketoanalogue. Monitoring of the serum phosphate levels is needed in case of concomitant administration of aluminum hydroxide.

Pregnancy & Breastfeeding use

There are no adequate data from the use of Amino Acid Keto Analogues in pregnant women. Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, embryonal/fetal development, parturition or postnatal development. Caution should be exercised when prescribing to pregnant women. No experience has been made so far with the use during lactation.