Amodiaquina
Amodiaquina Uses, Dosage, Side Effects, Food Interaction and all others data.
A 4-aminoquinoquinoline compound with anti-inflammatory properties.
Amodiaquina, a 4-aminoquinoline similar to chloroquine in structure and activity, has been used as both an antimalarial and an anti-inflammatory agent for more than 40 years. Amodiaquina is at least as effective as chloroquine, and is effective against some chloroquine-resistant strains, although resistance to amodiaquine has been reported. The mode of action of amodiaquine has not yet been determined. 4-Aminoquinolines depress cardiac muscle, impair cardiac conductivity, and produce vasodilatation with resultant hypotension. They depress respiration and cause diplopia, dizziness and nausea.
Trade Name | Amodiaquina |
Generic | Amodiaquine |
Amodiaquine Other Names | Amodiaquina, Amodiaquine, Amodiaquinum |
Type | |
Formula | C20H22ClN3O |
Weight | Average: 355.861 Monoisotopic: 355.145140048 |
Groups | Approved, Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Amodiaquina is an antimalarial drug.
For treatment of acute malarial attacks in non-immune subjects.
How Amodiaquina works
The mechanism of plasmodicidal action of amodiaquine is not completely certain. Like other quinoline derivatives, it is thought to inhibit heme polymerase activity. This results in accumulation of free heme, which is toxic to the parasites. The drug binds the free heme preventing the parasite from converting it to a form less toxic. This drug-heme complex is toxic and disrupts membrane function.
Toxicity
LD50 (mouse, intraperitoneal) 225 mg/kg, LD50 (mouse, oral) 550 mg/kg. Symptoms of overdose include headache, drowsiness, visual disturbances, vomiting, hypokalaemia, cardiovascular collapse and cardiac and respiratory arrest. Hypotension, if not treated, may progress rapidly to shock. Electrocardiograms (ECG) may reveal atrial standstill, nodal rhythm, prolonged intraventricular conduction time, broadening of the QRS complex, and progressive bradycardia leading to ventricular fibrillation and/or arrest.
Elimination Route
Rapidly absorbed following oral administration.
Half Life
5.2 ± 1.7 (range 0.4 to 5.5) minutes
Innovators Monograph
You find simplified version here Amodiaquina