Amrinona

Amrinona Uses, Dosage, Side Effects, Food Interaction and all others data.

Amrinona (or inamrinone) is a type 3 pyridine phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure.

Amrinona is a positive inotropic cardiotonic with vasodilator properties, phosphodiesterase inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.

Trade Name Amrinona
Generic Amrinone
Amrinone Other Names Amrinona, Amrinone, Amrinonum, Inamrinone
Type
Formula C10H9N3O
Weight Average: 187.198
Monoisotopic: 187.074561925
Protein binding

10 to 49%

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Amrinona
Amrinona

Uses

Amrinona is a positive inotropic agent and phosphodiesterase inhibitor used in the management of treatment of congestive heart failure.

Used in the treatment of congestive heart failure.

How Amrinona works

Amrinona is a phosphodiesterase inhibitor (PDE3), resulting in increased cAMP and cGMP which leads to an increase in the calcium influx like that caused by beta-agonists resulting in increased inotropic effect.

Volume of Distribution

  • 1.2 L/kg [normal volunteers]

Half Life

5 to 8 hours

Elimination Route

The primary route of excretion in man is via the urine as both inamrinone and several metabolites (N-glycolyl, N-acetate, O-glucuronide and N-glucuronide).

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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