AMSA P-D

AMSA P-D Uses, Dosage, Side Effects, Food Interaction and all others data.

Aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.

AMSA P-D is an aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.

Table Of contents

• AMSA P-D
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	AMSA P-D
Generic	Amsacrine
Amsacrine Other Names	Acridinyl anisidide, Amsacrina, Amsacrine, Amsacrinum, m-AMSA, mAMSA
Type
Formula	C21H19N3O3S
Weight	Average: 393.459 Monoisotopic: 393.114712179
Protein binding	96-98%
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

AMSA P-D is a cytotoxic agent used to induce remission in acute adult leukemia that is not adequately responsive to other agents.

For treatment of acute myeloid leukaemia.

AMSA P-D is also used to associated treatment for these conditions: Leukemia, Acute, Refractory Leukemia

How AMSA P-D works

AMSA P-D binds to DNA through intercalation and external binding. It has a base specificity for A-T pairs. Rapidly dividing cells are two to four times more sensitive to amsacrine than are resting cells. AMSA P-D appears to cleave DNA by inducing double stranded breaks. AMSA P-D also targets and inhibits topoisomerase II. Cytotoxicity is greatest during the S phase of the cell cycle when topoisomerase levels are at a maximum.

Toxicity

Symptoms of overdose include nausea and vomiting, diarrhea, some cardiotoxicity (rarely).

Food Interaction

No interactions found.

Elimination Route

Poorly absorbed

Half Life

8-9 hours

Innovators Monograph

You find simplified version here AMSA P-D