Antirex

Antirex Uses, Dosage, Side Effects, Food Interaction and all others data.

A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.

Antirex is a short and rapid-acting anticholinesterase drug. Its effect is manifest within 30 to 60 seconds after injection and lasts an average of 10 minutes. Antirex's pharmacologic action is due primarily to the inhibition or inactivation of acetylcholinesterase at sites of cholinergic transmission. Nicotinic acetylcholine (nAChR)receptors are found throughout the body, especially on muscle. Stimulation of these receptors causes to muscle contraction. In myasthenia gravis the body's immune system destroys many of the nicotinic acetylcholine receptors, so that the muscle becomes less responsive to nervous stimulation. Antirex chloride increases the amount of acetylcholine at the nerve endings. Increased levels of acetylcholine allow the remaining receptors to function more efficiently.

Trade Name Antirex
Availability Discontinued
Generic Edrophonium
Edrophonium Other Names Edrophonium ion
Related Drugs pyridostigmine, neostigmine, Mestinon, sugammadex, Bridion
Type
Formula C10H16NO
Weight Average: 166.2401
Monoisotopic: 166.123189139
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Antirex
Antirex

Uses

Antirex is a cholinesterase inhibitor used to diagnose and evaluate myasthenia gravis.

For the differential diagnosis of myasthenia gravis and as an adjunct in the evaluation of treatment requirements in this disease. It may also be used for evaluating emergency treatment in myasthenic crises.

Antirex is also used to associated treatment for these conditions: Myasthenia Gravis, Neuromuscular Blockade, Respiratory Depression

How Antirex works

Antirex works by prolonging the action acetylcholine, which is found naturally in the body. It does this by inhibiting the action of the enzyme acetylcholinesterase. Acetylcholine stimulates nicotinic and muscarinic receptors. When stimulated, these receptors have a range of effects.

Toxicity

With drugs of this type, muscarine-like symptoms (nausea, vomiting, diarrhea, sweating, increased bronchial and salivary secretions and bradycardia) often appear with overdosage (cholinergic crisis).

Food Interaction

No interactions found.

Volume of Distribution

  • 1.6±0.4 L/kg [Adults]
  • 2.2±1.5 L/kg [Children (0.08-10 yrs)]
  • 1.8±1.2 L/kg [Elderly (65-75 yrs)]

Elimination Route

Rapidly absorbed.

Half Life

Distribution half-life is 7 to 12 minutes. Elimination half-life is 33 to 110 minutes.

Clearance

  • 6.8 +/- 2. mL/kg/min [Adults]
  • 6.4 +/- 3.9 mL/kg/min [Children (0.08-10 yrs)]
  • 2.9 +/- 1.9 mL/kg/min [Elderly (65-75 yrs)]

Elimination Route

Antirex is primarily renally excreted with 67% of the dose appearing in the urine. Hepatic metabolism and biliary excretion have also been demonstrated in animals

Innovators Monograph

You find simplified version here Antirex

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0002448
http://classyfire.wishartlab.com/tax_nodes/C0002279
http://classyfire.wishartlab.com/tax_nodes/C0000284
http://classyfire.wishartlab.com/tax_nodes/C0000284
http://classyfire.wishartlab.com/tax_nodes/C0004655
http://classyfire.wishartlab.com/tax_nodes/C0004647
http://classyfire.wishartlab.com/tax_nodes/C0004646
http://classyfire.wishartlab.com/tax_nodes/C0000503
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0000323
http://classyfire.wishartlab.com/tax_nodes/C0003865
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0002449
http://classyfire.wishartlab.com/tax_nodes/C0003609
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:251408
http://www.hmdb.ca/metabolites/HMDB0015145
http://www.genome.jp/dbget-bin/www_bget?cpd:C06976
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3202
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507530
https://www.chemspider.com/Chemical-Structure.3090.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=120262
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=3752
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=251408
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1104
https://zinc.docking.org/substances/ZINC000000001341
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000562
http://www.pharmgkb.org/drug/PA449437
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/EDR
http://www.rxlist.com/cgi/generic3/edrophonium.htm
https://www.drugs.com/mtm/edrophonium.html
https://en.wikipedia.org/wiki/Edrophonium
*** Taking medicines without doctor's advice can cause long-term problems.
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