Edrophonium
Edrophonium Uses, Dosage, Side Effects, Food Interaction and all others data.
A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
Edrophonium is a short and rapid-acting anticholinesterase drug. Its effect is manifest within 30 to 60 seconds after injection and lasts an average of 10 minutes. Edrophonium's pharmacologic action is due primarily to the inhibition or inactivation of acetylcholinesterase at sites of cholinergic transmission. Nicotinic acetylcholine (nAChR)receptors are found throughout the body, especially on muscle. Stimulation of these receptors causes to muscle contraction. In myasthenia gravis the body's immune system destroys many of the nicotinic acetylcholine receptors, so that the muscle becomes less responsive to nervous stimulation. Edrophonium chloride increases the amount of acetylcholine at the nerve endings. Increased levels of acetylcholine allow the remaining receptors to function more efficiently.
| Trade Name | Edrophonium |
| Availability | Discontinued |
| Generic | Edrophonium |
| Edrophonium Other Names | Edrophonium ion |
| Related Drugs | pyridostigmine, neostigmine, Mestinon, sugammadex, Bridion |
| Type | Injection |
| Formula | C10H16NO |
| Weight | Average: 166.2401 Monoisotopic: 166.123189139 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Edrophonium is a cholinesterase inhibitor used to diagnose and evaluate myasthenia gravis.
For the differential diagnosis of myasthenia gravis and as an adjunct in the evaluation of treatment requirements in this disease. It may also be used for evaluating emergency treatment in myasthenic crises.
Edrophonium is also used to associated treatment for these conditions: Myasthenia Gravis, Neuromuscular Blockade, Respiratory Depression
How Edrophonium works
Edrophonium works by prolonging the action acetylcholine, which is found naturally in the body. It does this by inhibiting the action of the enzyme acetylcholinesterase. Acetylcholine stimulates nicotinic and muscarinic receptors. When stimulated, these receptors have a range of effects.
Toxicity
With drugs of this type, muscarine-like symptoms (nausea, vomiting, diarrhea, sweating, increased bronchial and salivary secretions and bradycardia) often appear with overdosage (cholinergic crisis).
Food Interaction
No interactions found.Edrophonium Drug Interaction
Unknown: zafirlukast, zafirlukast, amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, epinephrine, epinephrine, methyldopa, methyldopa, lorazepam, lorazepam, ipratropium, ipratropium, diphenhydramine, diphenhydramine, sucralfate, sucralfate, citalopram, citalopram, albuterol / ipratropium, albuterol / ipratropium
Edrophonium Disease Interaction
Major: bradycardia, bronchospasm, coronary artery disease, parkinsonism, PUD, seizuresModerate: hyperthyroidism
Volume of Distribution
- 1.6±0.4 L/kg [Adults]
- 2.2±1.5 L/kg [Children (0.08-10 yrs)]
- 1.8±1.2 L/kg [Elderly (65-75 yrs)]
Elimination Route
Rapidly absorbed.
Half Life
Distribution half-life is 7 to 12 minutes. Elimination half-life is 33 to 110 minutes.
Clearance
- 6.8 +/- 2. mL/kg/min [Adults]
- 6.4 +/- 3.9 mL/kg/min [Children (0.08-10 yrs)]
- 2.9 +/- 1.9 mL/kg/min [Elderly (65-75 yrs)]
Elimination Route
Edrophonium is primarily renally excreted with 67% of the dose appearing in the urine. Hepatic metabolism and biliary excretion have also been demonstrated in animals
Innovators Monograph
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