Anusol Plus HC
Anusol Plus HC Uses, Dosage, Side Effects, Food Interaction and all others data.
Zinc oxide: 15.25% w/wBenzyl alcohol: 0.39% w/wBenzyl benzoate: 1.01% w/wBenzyl cinnamate: 0.15% w/wLanolin (hypoallergenic): 4.00% w/w Zinc oxide: A dermatological agent with astringent, soothing and protective properties. Benzyl alcohol: A local anaesthetic with disinfectant properties. Benzyl benzoate: An acaricide and has been used as a pediculicide, insect repellent and pharmaceutical solubilising agent. It is a constituent of many natural balsams and is one of the principal esters of Peru Balsam. Benzyl cinnamate: This is the other principal ester of Peru Balsal BPC 1973. It is synthetised from benzyl alcohol and cinnamic acid which has antibacterial and antifungal properties. Peru Balsam is categorised as having a mild antiseptic action because of cinnamic acid and its derivatives present. Lanolin: Resembles the sebaceous secretions of human skin. The grade (hypoallergenic) used is manufactured so as to exclude many sensitising substances present in the lanolin.
| Trade Name | Anusol Plus HC |
| Generic | Zinc oxide + Benzyl alcohol + Benzyl benzoate + Benzyl cinnamate + Lanolin |
| Type | |
| Therapeutic Class | Drugs used in diaper rash, Sunblock Preparation |
| Manufacturer | Church & Dwight UK Ltd |
| Available Country | United Kingdom |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
In the treatment of Napkin rash, Eczema, Bedsores, Acne, Minor burns, Surface wounds, Sunburn, Chilblains.
Anusol Plus HC is also used to associated treatment for these conditions: Cold Sore, Fever blister, Head Lice Infestation, Insect Bites, Orofacial Pain, Skin Irritation, Sunburn, Abrasions, Minor burns, Superficial WoundsLice, ScabiesEye lubrication, Skin protectionAcute Wounds, Burns first degree, Burns second degree, Dermatitis, Eczematous, Diaper Rash, Herpes Labialis, Injuries to the Nipple (Fissures and Cracks) Resulting Breastfeeding, Intertrigo, Pain, Pruritus, Sensitive Skin, Skin Irritation, Skin candida, Sunburn, Wounds, Chafing, Damaged skin, Dry, cracked skin, Facial rash, Heat rash, Superficial Wounds, Watery skin lesions, Astringent, Nutritional supplementation
How Anusol Plus HC works
Benzyl alcohol inhibits lice from closing their respiratory spiracles, allowing the vehicle to obstruct the spiracles and causing the lice to asphyxiate.
Benzyl benzoate exerts toxic effects on the nervous system of the parasite, resulting in its death. It is also toxic to mite ova, though its exact mechanism of action is unknown. In vitro, benzyl benzoate has been found to kill the Sarcoptes mite within 5 minutes.
Lanolin is an emollient. Emollients soften the skin by forming an occlusive oil film on the stratum corneum layer of the epithelium, thus decreasing the transepidermal water loss .
It acts by providing a physical barrier to prevent skin irritation and help heal damaged skin.
Dosage
Anusol Plus HC dosage
Apply a thin layer with suitable covering where necessary. Renew application as required. No distinction is required between indications or between adults, children and the elderly. Topical cream for external use only.
Side Effects
Side effects include local hypersensitivity occasionally.
Toxicity
1250 mg/kg (rat, oral) LD50 400 mg/kg IPR-RAT LD50 2000 mg/kg SKN-RBT LD50 53 mg/kg IVN-RAT LD50 2500 mg/kg ORL-GPG LD50
Oral, rabbit: LD50 = 1680 mg/kg; Skin, rabbit: LD50 = 4000 mg/kg. Symptoms of overdose include blister formation, crusting, itching, oozing, reddening, or scaling of skin; difficulty in urinating (dribbling); jerking movements; sudden loss of consciousness.
Studies have shown a positive association between atopic dermatitis and lanolin contact allergy . The prevalence of lanolin allergy is low (1.8%-2.5%) . Patch testing with lanolin is helpful in patients with dermatitis and suspected cosmetic allergy .
The acute dermal LD50 of lanolin oil was > 10 mL/kg for rabbits .
Acute oral toxicity (LD50): 7950 mg/kg [Mouse].
Precaution
For external use only and should not be allowed to come into contact with the eyes and the mucous membranes. Instruct patients not to smoke or go near naked flames- risk of severe burns. Fabric (clothing, bedding, dressings etc) that has been in contact with this product burns more easily and is a serious fire hazard. Washing clothing and bedding may reduce product build-up but not totally remove it.
Interaction
No formal drug interaction studies to date.
Irritant to eyes and mucous membranes, allergic dermatitis reactions, drying effects in the elderly.
Volume of Distribution
Intended for local use only, no systemic absorption.
Elimination Route
No data are available on percutaneous absorption of benzyl benzoate. Some older studies have suggested some percutaneous absorption, however the amount was not quantified.
No significant percutaneous absorption from topically applied zinc oxide.
Half Life
Intended for local use only, no systemic absorption.
Clearance
Intended for local use only, no systemic absorption.
Elimination Route
Intended for local use only, no systemic absorption.
Pregnancy & Breastfeeding use
There are no known contraindications in pregnancy & lactation.
Contraindication
Hypersensitivity to any of the ingredients.
Acute Overdose
No case of overdose has been reported. If large amounts are swallowed accidentally, this may cause vomiting, diarrhoea, CNS stimulation and convulsions. Symptomatic treatment should be provided.
Storage Condition
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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