Apo-Methazolamide

Apo-Methazolamide Uses, Dosage, Side Effects, Food Interaction and all others data.

A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.

Apo-Methazolamide is topical carbonic anhydrase inhibitor. Apo-Methazolamide is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers. Apo-Methazolamide is a sulfonamide derivative; however, it does not have any clinically significant antimicrobial properties. Although methazolamide achieves a high concentration in the cerebrospinal fluid, it is not-considered an effective anticonvulsant. Apo-Methazolamide has a weak and transient diuretic effect, therefore use results in an increase in urinary volume, with excretion of sodium, potassium and chloride.

Table Of contents

• Apo-Methazolamide
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Apo-Methazolamide
Availability	Prescription only
Generic	Methazolamide
Methazolamide Other Names	Metazolamida, Methazolamid, Méthazolamide, Methazolamide, Methazolamidum, Methenamide, Neptazaneat
Related Drugs	acetazolamide, nadolol, pilocarpine ophthalmic, Diamox, Combigan, mitomycin ophthalmic
Type
Formula	C5H8N4O3S2
Weight	Average: 236.26 Monoisotopic: 236.003782482
Protein binding	55%
Groups	Approved
Therapeutic Class
Manufacturer
Available Country	Canada, United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Apo-Methazolamide is a carbonic anhydrase inhibitor used to treat open angle glaucoma and acute angle closure glaucoma.

For treatment of chronic open-angle glaucoma and acute angle-closure glaucoma

Apo-Methazolamide is also used to associated treatment for these conditions: Open-angle Glaucoma (OAG), Acute Angle closure glaucoma

How Apo-Methazolamide works

Apo-Methazolamide is a potent inhibitor of carbonic anhydrase. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport.

Toxicity

Electrolyte imbalance, development of an acidotic state, and central nervous system effects might be expected to occur in the case of an overdose.

Food Interaction

• Drink plenty of fluids.
• Take with food.

Apo-Methazolamide Drug Interaction

Moderate: brinzolamide ophthalmic, brinzolamide ophthalmic, duloxetine, duloxetineUnknown: sulfamethoxazole / trimethoprim, sulfamethoxazole / trimethoprim, brimonidine / timolol ophthalmic, brimonidine / timolol ophthalmic, meperidine, meperidine, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acids, bimatoprost ophthalmic, bimatoprost ophthalmic, pregabalin, pregabalin, cyanocobalamin, cyanocobalamin, cholecalciferol, cholecalciferol

Apo-Methazolamide Disease Interaction

Major: bone marrow depression/blood dyscrasias, adrenal insufficiency, closed-angle glaucoma, hypokalemia, hyponatremia, severe kidney disease, severe liver diseaseModerate: respiratory acidosis, diabetes mellitus, gout, metabolic acidosis

Volume of Distribution

• 17 to 23 L

Elimination Route

Apo-Methazolamide is well absorbed from the gastrointestinal tract.

Half Life

14 hours

Innovators Monograph

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