AT 10
AT 10 Uses, Dosage, Side Effects, Food Interaction and all others data.
A vitamin D that can be regarded as a reduction product of vitamin D2.
AT 10 is hydroxylated in the liver to 25-hydroxydihydrotachysterol, which is the major circulating active form of the drug. It does not undergo further hydroxylation by the kidney and therefore is the analogue of 1, 25-dihydroxyvitamin D. AT 10 is effective in the elevation of serum calcium by stimulating intestinal calcium absorption and mobilizing bone calcium in the absence of parathyroid hormone and of functioning renal tissue. AT 10 also increases renal phosphate excretion.
| Trade Name | AT 10 |
| Availability | Discontinued |
| Generic | Dihydrotachysterol |
| Dihydrotachysterol Other Names | Anti-tetany substance 10, Dihidrotaquisterol, Dihydrotachysterol, Dihydrotachysterolum |
| Related Drugs | Prolia, hydrochlorothiazide, alendronate, calcitriol, calcitonin, Fosamax, ergocalciferol, calcium carbonate, Caltrate |
| Type | |
| Formula | C28H46O |
| Weight | Average: 398.6642 Monoisotopic: 398.354866094 |
| Protein binding | >99% |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
AT 10 is a synthetic analog of vitamin D that does not require renal activation like vitamin D2 or Vitamin D3.
Used for the prevention and treatment of rickets or osteomalacia, and to manage hypocalcemia associated with hypoparathyroidism or pseudohypoparathyroidism. Also used for the treatment of vitamin D dependent rickets, rickets or osteomalacia secondary to long-term high dose anticonvulsant therapy, early renal osteodystrophy, osteoporosis (in conjunction with calcium), and hypophosphatemia associated with Fanconi syndrome (with treatment of acidosis).
AT 10 is also used to associated treatment for these conditions: Hypoparathyroidism, Pseudohypoparathyroidism
How AT 10 works
Once hydroxylated to 25-hydroxydihydrotachysterol, the modified drug binds to the vitamin D receptor. The bound form of the vitamin D receptor serves as a transcriptional regulator of bone matrix proteins, inducing the expression of osteocalcin and suppressing synthesis of type I collagen. Vitamin D (when bound to the vitamin D receptor)stimulates the expression of a number of proteins involved in transporting calcium from the lumen of the intestine, across the epithelial cells and into blood. This stimulates intestinal calcium absorption and increases renal phosphate excretion. These are functions that are normally carried out by the parathyroid hormone.
Toxicity
Toxicity associated with dihydrotachysterol is similar to that seen with large doses of vitamin D.
Food Interaction
No interactions found.AT 10 Drug Interaction
Unknown: anastrozole, anastrozole, hydroxyzine, hydroxyzine, diphenhydramine, diphenhydramine, glatiramer, glatiramer, liothyronine, liothyronine, methylprednisolone, methylprednisolone, benzoyl peroxide / clindamycin topical, benzoyl peroxide / clindamycin topical, dicloxacillin, dicloxacillin, gabapentin, gabapentin, chorionic gonadotropin , chorionic gonadotropin
AT 10 Disease Interaction
Major: arrhythmia, electrolyte imbalance, renal dysfunctionModerate: hepatobiliary dysfunction
Innovators Monograph
You find simplified version here AT 10
