Azlocilline

Azlocilline Uses, Dosage, Side Effects, Food Interaction and all others data.

Azlocilline is a semisynthetic ampicillin-derived acylureido penicillin.

Similar to mezlocillin and piperacillin, azlocillin is an acylampicillin that exhibits an extended-spectrum of activity and in vitro potency that is greater than that of the carboxy penicillins. Azlocilline is shown to be effective against a broad spectrum of bacteria, including Pseudomonas aeruginosa and enterococci.

Table Of contents

• Azlocilline
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Azlocilline
Generic	Azlocillin
Azlocillin Other Names	Azlocilina, Azlocillin, Azlocilline, Azlocillinum
Type
Formula	C20H23N5O6S
Weight	Average: 461.492 Monoisotopic: 461.136904183
Protein binding	20 to 46% bound to plasma proteins
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

For the treatment of infections caused by Pseudomonas aeruginosa, Escherichia coli, and Haemophilus influenzae.

How Azlocilline works

By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, azlocillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that azlocillin interferes with an autolysin inhibitor.

Elimination Route

Not significantly absorbed from the gastrointestinal tract.

Half Life

Mean elimination half-life is 1.3 to 1.5 hours. Longer in neonates, and 2 to 6 hours in patients with renal impairment.

Innovators Monograph

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