Azosémide

Azosémide Uses, Dosage, Side Effects, Food Interaction and all others data.

Azosémide is a loop diuretic used to treat hypertension, edema, and ascites.

Diuretic affects upon oral administration match those of furosemide. However, upon intravenous administration azosemide displays 5.5 to 8 times greater effect.

Trade Name	Azosémide
Generic	Azosemide
Azosemide Other Names	azosemida, azosémide, Azosemide, azosemidum
Type
Formula	C12H11ClN6O2S2
Weight	Average: 370.838 Monoisotopic: 370.007342713
Protein binding	> 95% 4% protein binding to 4% human serum albumin at azosemide concentrations of 10-100ug/ml, using equilibrium dialysis.
Groups	Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

How Azosémide works

Exact mechanism of action is unclear. However, it acts primarily on the loop of Henle, in both the medullary and cortical segments of the thick ascending limb.

Volume of Distribution

Poor affinity for human tissue. Small apparent post-pseudodistribution Vd of 0.262 l/kg.

Elimination Route

Peak plasma concentrations are achieved in 3-4 hours when azosemide is administered to healthy humans in a fasting state. There is an absorption lag time of approximately 1 hour. Oral bioavailability estimated to be 20.4%

Half Life

Terminal half life 2-3 hours.

Elimination Route

Total body clearance 112ml/min. Renal clearance 41.6ml/min. Actively secreted in the renal proximal tubule of humans. This may or may not involve a nonspecific organic acid secretory pathway. There is thus a potential for disease states and other organic acids such as NSAIDs which affect the organic acid transport pathway to affect the efficacy of azosemide.

Innovators Monograph

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