Azosémide
Azosémide Uses, Dosage, Side Effects, Food Interaction and all others data.
Azosémide is a loop diuretic used to treat hypertension, edema, and ascites.
Diuretic affects upon oral administration match those of furosemide. However, upon intravenous administration azosemide displays 5.5 to 8 times greater effect.
| Trade Name | Azosémide |
| Generic | Azosemide |
| Azosemide Other Names | azosemida, azosémide, Azosemide, azosemidum |
| Type | |
| Formula | C12H11ClN6O2S2 |
| Weight | Average: 370.838 Monoisotopic: 370.007342713 |
| Protein binding | > 95% 4% protein binding to 4% human serum albumin at azosemide concentrations of 10-100ug/ml, using equilibrium dialysis. |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
How Azosémide works
Exact mechanism of action is unclear. However, it acts primarily on the loop of Henle, in both the medullary and cortical segments of the thick ascending limb.
Volume of Distribution
Poor affinity for human tissue. Small apparent post-pseudodistribution Vd of 0.262 l/kg.
Elimination Route
Peak plasma concentrations are achieved in 3-4 hours when azosemide is administered to healthy humans in a fasting state. There is an absorption lag time of approximately 1 hour. Oral bioavailability estimated to be 20.4%
Half Life
Terminal half life 2-3 hours.
Elimination Route
Total body clearance 112ml/min. Renal clearance 41.6ml/min. Actively secreted in the renal proximal tubule of humans. This may or may not involve a nonspecific organic acid secretory pathway. There is thus a potential for disease states and other organic acids such as NSAIDs which affect the organic acid transport pathway to affect the efficacy of azosemide.
Innovators Monograph
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