Bacillus Anthracis Immune Globulin Human

Bacillus Anthracis Immune Globulin Human Uses, Dosage, Side Effects, Food Interaction and all others data.

Anthrax immune globulin is a human antibody given with antibiotics for the treatment of anthrax. It is derived from the plasma of humans immunized with BioThrax (adsorbed anthrax vaccine), which is then further purified. Available as the product Anthrasil (FDA), the result is a solution for slow IV infusion containing polyclonal antibodies that bind the protective antigen (PA) component of Bacillus anthracis lethal and edema toxins. This binding of antibody to PA prevents PA-mediated cellular entry of toxic factors. It is administered in combination with appropriate antibiotic therapy as the immunoglobulin itself is not known to have direct antibacterial activity against anthrax bacteria, which otherwise may continue to grow and produce anthrax toxins.

Bacillus Anthracis Immune Globulin Human
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Uses during Pregnancy
Uses during Breastfeeding
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Trade Name	Bacillus Anthracis Immune Globulin Human
Generic	Anthrax immune globulin human
Anthrax immune globulin human Other Names	Anthrax immune globulin (human), Anthrax immune globulin human, Anthrax immunoglobulin (human), Bacillus anthracis immune globulin human
Type
Groups	Approved
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Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Bacillus Anthracis Immune Globulin Human is an immunizing agent used for the treatment of inhalational anthrax in adult and pediatric patients in combination with antibacterial agents.

Anthrax immune globulin is indicated for the treatment of inhalational anthrax in adult and pediatric patients in combination with appropriate antibacterial drugs.

Bacillus Anthracis Immune Globulin Human is also used to associated treatment for these conditions: Inhaled anthrax caused by Bacillus anthracis

How Bacillus Anthracis Immune Globulin Human works

Polyclonal anthrax immune globulin is a passive immunizing agent that neutralizes anthrax toxin by binding to Protective Antigen (PA) to prevent PA-mediated cellular entry of anthrax edema factor and lethal factor. It is administered in combination with appropriate antibiotic therapy as the immunoglobulin itself is not known to have direct antibacterial activity against anthrax bacteria, which otherwise may continue to grow and produce anthrax toxins.

Toxicity

The most common adverse reactions to Anthrasil observed in >5% of healthy volunteers in clinical trials were headache, infusion site pain and swelling, nausea, and back pain.

Food Interaction

No interactions found.

Volume of Distribution

5714.8 mL

Elimination Route

Peak levels were reached immediately after infusion and then declined over the duration of study (84 days). Mean activity remained above the lower limit of quantitation (5 milliunits per mL) over the entire 84-day post-dose period for the three doses studied. Cmax was found to be 83.0 mU/mL while Tmax was found to be 0.116 days.