Bang Ping

Bang Ping Uses, Dosage, Side Effects, Food Interaction and all others data.

Bang Ping is a preparation of Bang Ping which is a quinolinone derivative. The mechanism of action is to specifically inhibit cellular phosphodiesterase III (PDE III) and suppress cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation.

Bang Ping reduces the symptoms of intermittent claudication, as indicated by an increased walking distance. Intermittent claudication is pain in the legs that occurs with walking and disappears with rest. The pain occurs due to reduced blood flow to the legs.

Trade Name Bang Ping
Availability Prescription only
Generic Cilostazol
Cilostazol Other Names Cilostazol, Cilostazole, Cilostazolum
Related Drugs pentoxifylline, Pletal, Trental, Pentoxil
Type
Formula C20H27N5O2
Weight Average: 369.4607
Monoisotopic: 369.216475133
Protein binding

95-98%

Groups Approved, Investigational
Therapeutic Class Peripheral Vasodilator drugs: Intermittent Claudication
Manufacturer
Available Country China
Last Updated: September 19, 2023 at 7:00 am
Bang Ping
Bang Ping

Uses

Bang Ping is used for the reduction of symptoms of intermittent claudication, as used by an increased walking distance.

Bang Ping is also used to associated treatment for these conditions: Intermittent Claudication

How Bang Ping works

Bang Ping and several of its metabolites are cyclic AMP (cAMP) phosphodiesterase III inhibitors (PDE III inhibitors), inhibiting phosphodiesterase activity and suppressing cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation.

Dosage

Bang Ping dosage

The recommended dosage of Bang Ping is 100 mg bid, taken at least half an hour before or two hours after breakfast and dinner.

A dose of 50 mg bid should be considered during coadministration of Fluconazole, Ketoconazole, Itraconazole, Erythromycin, Clarithromycin, Fluvoxamine, Fluoxetine, Nefazodone, Sertraline and Diltiazem.

Side Effects

The most common side effects are headache, diarrhoea, vomiting, leg cramps, rash etc. The less frequent side effects are anorexia and edema.

Toxicity

Information on acute overdosage with cilostazol in humans is limited. The signs and symptoms of an acute overdose can be anticipated to be those of excessive pharmacologic effect: severe headache, diarrhea, hypotension, tachycardia, and possibly cardiac arrhythmias. The oral LD50 of cilostazol is >5.0 g/kg in mice and rats and >2.0 g/kg in dogs.

Precaution

Bang Ping should be used with caution in patients with any degree of heart failure. There is no information with respect to the efficacy or safety of the concurrent use of Bang Ping and Clopidogrel.

Interaction

Co-admin with drugs that affect CYP3A4 (erythromycin, other macrolides, diltiazem) or CYP2C19 (omeprazole) may influence the pharmacokinetics of cilostazol.

Food Interaction

  • Avoid grapefruit products.
  • Take on an empty stomach. A high fat meal will increase absorption.

[Moderate] GENERALLY AVOID: Grapefruit juice may increase the plasma concentrations of cilostazol.

The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits.

The extent and clinical significance are unknown.

Moreover, pharmacokinetic alterations associated with interactions involving grapefruit juice are often subject to a high degree of interpatient variability.

MANAGEMENT: Until more information is available, the manufacturer recommends avoiding consumption of grapefruit juice during cilostazol therapy.

Orange juice is not expected to interact with cilostazol.

Elimination Route

Bang Ping is absorbed after oral administration. A high fat meal increases absorption, with an approximately 90% increase in Cmax and a 25% increase in AUC. Absolute bioavailability is not known.

Half Life

11-13 hours.

Elimination Route

Bang Ping is extensively metabolized by hepatic cytochrome P-450 enzymes, mainly 3A4, and, to a lesser extent, 2C19, with metabolites largely excreted in urine. Bang Ping is eliminated predominately by metabolism and subsequent urinary excretion of metabolites. The primary route of elimination was via the urine (74%), with the remainder excreted in feces (20%). No measurable amount of unchanged cilostazol was excreted in the urine, and less than 2% of the dose was excreted as 3,4-dehydro-cilostazol. About 30% of the dose was excreted in urine as 4'-trans-hydroxy-cilostazol.

Pregnancy & Breastfeeding use

There are no adequate and well controlled studies in pregnant women. Transfer of Bang Ping into milk has been reported in experimental animals. Because of the potential risk to nursing infants, a decision should be made to discontinue nursing or to discontinue Bang Ping.

Contraindication

Bang Ping is contraindicated in patients with congestive heart failure of any severity. Bang Ping is also contraindicated in patients with known or suspected hypersensitivity to any of its components.

Special Warning

Paediatric use: The safety and effectiveness of Bang Ping in paediatric patients have not been established.

Acute Overdose

Severe headache, diarrhoea, hypotension, tachycardia, and possibly cardiac arrhythmias. Careful observation and supportive treatment are recommended.

Storage Condition

Store in a cool & dry place, protected from light and moisture

Innovators Monograph

You find simplified version here Bang Ping

Bang Ping contains Cilostazol see full prescribing information from innovator Bang Ping Monograph, Bang Ping MSDS, Bang Ping FDA label

*** Taking medicines without doctor's advice can cause long-term problems.
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