Benzylhexadecyldimethylammonium
Benzylhexadecyldimethylammonium Uses, Dosage, Side Effects, Food Interaction and all others data.
Benzylhexadecyldimethylammonium is a C16 alkyl benzalkonium chloride derivative with an amphipathic property which allows it to be used in different types of formulations. It is a quaternary ammonium salt that acts as an antiseptic against a variety of bacteria and fungi. Benzylhexadecyldimethylammonium is approved by the FDA for its use in over-the-counter products as a skin protectant. By Health Canada, it is also approved for its use in over-the-counter products.
Benzylhexadecyldimethylammonium is an antimicrobial agent and it has shown to be effective against both gram-positive, gram-negative bacteria and fungi. From this property, it has been shown to present a better activity against the gram-negative organisms.
| Trade Name | Benzylhexadecyldimethylammonium |
| Generic | Cetalkonium |
| Cetalkonium Other Names | Benzylhexadecyldimethylammonium, Cetalkonium ion |
| Type | |
| Formula | C25H46N |
| Weight | Average: 360.649 Monoisotopic: 360.362476905 |
| Protein binding | As cetalkonium is not absorbed, this pharmacokinetic property is not relevant. |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Benzylhexadecyldimethylammonium is an antiseptic used as a preservative or to treat certain topical infections.
Benzylhexadecyldimethylammonium is used as a surfactant, germicide, fungicide, mildew preventive agents in silicone-based water repellents, emulsifier, disinfectant, topical anti-infective, and antiseptic antimicrobial for pharmaceuticals. For its chemical properties and its antiseptical characteristics, cetalkonium can be used in a wide variety of products as part of the formulations and it is also determined to be an active antiseptic ingredient in over-the-counter preparations.
Benzylhexadecyldimethylammonium is also used to associated treatment for these conditions: Pain
How Benzylhexadecyldimethylammonium works
The activity of cetalkonium is based on the creation of a positive charge which permits a bio-adhesive property to negative surfaces. This property allows cetalkonium to disrupt the cell membrane, inactivate enzymes and denature proteins. This type of mechanism allows this type of agents to present a broad spectrum.
Toxicity
A fatal dose is reported to be in the range of 1-3 g and the LD50 observed in different preclinical studies has been from 60-400 mg/kg depending on the animal species and route of administration.
Food Interaction
No interactions found.Volume of Distribution
As cetalkonium is not absorbed, this pharmacokinetic property is not relevant.
Elimination Route
Benzylhexadecyldimethylammonium is used mainly topically and it is not absorbed. When administered orally and parenterally, cetalkonium absorption may happen but it is very insignificant.
Half Life
As cetalkonium is not absorbed, this pharmacokinetic property is not relevant.
Clearance
As cetalkonium is not absorbed, this pharmacokinetic property is not relevant.
Elimination Route
As cetalkonium is not absorbed, this pharmacokinetic property is not relevant. When administered orally, most of the administered dose is excreted unchanged in the feces as it is very poorly absorbed.
Innovators Monograph
You find simplified version here Benzylhexadecyldimethylammonium
