Bexxartherapeutic

Bexxartherapeutic Uses, Dosage, Side Effects, Food Interaction and all others data.

Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine).

Bexxartherapeutic binds to the CD20 antigen, which is predominantly expressed on mature B cells and on >90% of B-cell non-Hodgkin's lympohomas. The antibody leads to selective killing of B-cells.

Bexxartherapeutic
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Uses during Pregnancy
Uses during Breastfeeding
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Trade Name	Bexxartherapeutic
Availability	Prescription only
Generic	Tositumomab
Tositumomab Other Names	Tositumomab
Related Drugs	methotrexate, rituximab, glucagon, Rituxan, cyclophosphamide, mannitol, vincristine, Imbruvica, Tubersol
Type
Formula	C₆₄₁₆H₉₈₇₄N₁₆₈₈O₁₉₈₇S₄₄
Weight	143859.7 Da
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country	United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Bexxartherapeutic is a monoclonal anti-CD20 antibody used to treat B-cell non-Hodgkin's lymphoma via a conjugated radioactive isotope.

For treatment of non-Hodgkin's lymphoma (CD20 positive, follicular)

How Bexxartherapeutic works

Binds to the CD20 antigen which is found on mature B lymphocytes. The antibody binding appears to induce apoptosis, complement-dependent cytotoxicity and cell death through ionizing radiation.