Biligrafin

Biligrafin Uses, Dosage, Side Effects, Food Interaction and all others data.

Biligrafin is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography.

Following intravenous administration of Cholografin Meglumine, iodipamide is carried to the liver where it is rapidly secreted. The contrast medium appears in the bile within 10 to 15 minutes after injection, thus permitting visualization of the hepatic and common bile ducts, even in cholecystectomized patients. The biliary ducts are readily visualized within about 25 minutes after administration, except in patients with impaired liver function. The gallbladder begins to fill within an hour after injection; maximum filling is reached after two to two and one-half hours. The contrast medium is finally eliminated in the feces without passing through the enterohepatic circulation, except for approximately 10 percent of the intravenously administered dose which is excreted through the kidneys.

Biligrafin
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Biligrafin
Availability	Prescription only
Generic	Iodipamide
Iodipamide Other Names	Adipiodona, Adipiodone, Adipiodonum, Iodipamide
Type
Formula	C₂₀H₁₄I₆N₂O₆
Weight	Average: 1139.7618 Monoisotopic: 1139.51199671
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Biligrafin is a contrast agent used in cholangiography and cholecystography.

Biligrafin is used as a contrast agent for cholecystography and intravenous cholangiography.

How Biligrafin works

Organic iodine compounds block x-rays as they pass through the body, thereby allowing body structures containing iodine to be delineated in contrast to those structures that do not contain iodine. The degree of opacity produced by these iodinated organic compounds is directly proportional to the total amount (concentration and volume) of the iodinated contrast agent in the path of the x-rays. Biligrafin's primary excretion through the hepato-biliary system and concentration in bile allows visualization of the gallbladder and biliary ducts.

Toxicity

Ionic radiocontrast agents like iodipamide are cytotoxic to renal cells. The toxic effects include apoptosis, cellular energy failure, disruption of calcium homeostasis, and disturbance of tubular cell polarity, and are thought to be linked to oxidative stress. Acute IV LD50 is 5000 mg/kg in rat, 3195 mg/kg in mouse, and 1200 mg/kg in dog.