Bis-hydroxycoumarin
Bis-hydroxycoumarin Uses, Dosage, Side Effects, Food Interaction and all others data.
Bis-hydroxycoumarin is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K. In addition to its clinical use, it is also used in biochemical experiments as an inhibitor of reductases.
Dicumarol is an coumarin-like compound found in sweet clover. It is used as an oral anticoagulant and acts by inhibiting the hepatic synthesis of vitamin K-dependent coagulation factors (prothrombin and factors VII, IX, and X).
| Trade Name | Bis-hydroxycoumarin |
| Generic | Dicoumarol |
| Dicoumarol Other Names | bis-hydroxycoumarin, Dicoumarol, Dicoumarolum, Dicumarol |
| Type | |
| Formula | C19H12O6 |
| Weight | Average: 336.295 Monoisotopic: 336.063388116 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For decreasing blood clotting. Often used along with heparin for treatment of deep vein thrombosis.
How Bis-hydroxycoumarin works
Dicumarol inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decresed prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots.
Toxicity
LD50=233 mg/kg (orally in mice); LD50=250 mg/kg (orally in rats)
Food Interaction
- Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include ginseng, ginkgo, ginger, and garlic.
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