Blonanserin

Blonanserin Uses, Dosage, Side Effects, Food Interaction and all others data.

Blonanserin is an atypical antipsychotic approved in Japan in January, 2008. It offers improved tolerability as it lacks side effects such as extrapyramidal symptoms, excessive sedation, or hypotension. As a second-generation (atypical) antipsychotic, it is significantly more efficacious in the treatment of the negative symptoms of schizophrenia compared to first-generation (typical) antipsychotics.

Blonanserin antagonizes dopamine and serotonin receptors to reduce symptoms of schizophrenia .

Blonanserin
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Blonanserin
Generic	Blonanserin
Blonanserin Other Names	Blonanserin
Type
Formula	C₂₃H₃₀FN₃
Weight	Average: 367.512 Monoisotopic: 367.242376141
Protein binding	Blonanserin is over 99.7% bound to plasma proteins . Serum albumin is the primary binder.
Groups	Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Used for the treatment of schizophrenia .

How Blonanserin works

Blonanserin binds to and inhibits dopamine receptors D2 and D3 as well as the serotonin receptor 5-HT2A with high affinity . Blonanserin has low affinity for other dopamine and serotonin receptors as well as muscarinic, adrenergic, and histamine receptors. This reduces dopaminergic and serotonergic neurotransmission which is thought to produce a reduction in positive and negative symptoms of schizophrenia respectively.

Toxicity

Oral LD50 of >500 mg/kg in mice .

Volume of Distribution

Blonanserin has a Vc of 9500 L and a Vt of 8560 L for a total Vd of 18060 L .

Elimination Route

Blonanserin has a Tmax of 1.5 h and a bioavailablity of 55% . Tmax has been observed to be prolonged and relative bioavailability increased when administered with food .

Half Life

Blonanserin has a half life of elimination of 10.7-16.2 h .

Clearance

Blonanserin has a clearance of 1230 L/h .

Elimination Route

57% of blonanserin is excreted in the urine and 30% in the feces . Only 5% of the drug in the feces is the parent drug with no parent drug excreted through the urine.