Botulinum Neurotoxin Type B Precursor

Botulinum Neurotoxin Type B Precursor Uses, Dosage, Side Effects, Food Interaction and all others data.

Neurotoxin produced by fermentation of clostridium botulinum type B. The protein exists in noncovalent association with hemagglutinin and nonhemagglutinin proteins as a neurotoxin complex. The neurotoxin complex is recovered from the fermentation process and purified through a series of precipitation and chromatography steps.

Botulinum Toxin Type B inhibits acetylcholine release at the neuromuscular junction via a three stage process: 1) Heavy Chain mediated neurospecific binding of the toxin, 2) internalization of the toxin by receptor-mediated endocytosis, and 3) ATP and pH dependent translocation of the Light Chain to the neuronal cytosol where it acts as a zinc-dependent endoprotease cleaving polypeptides essential for neurotransmitter release.

Botulinum Neurotoxin Type B Precursor
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
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Interaction With other Medicine
Contradiction
Storage

Trade Name	Botulinum Neurotoxin Type B Precursor
Generic	Botulinum toxin type B
Botulinum toxin type B Other Names	Botulin B, Botulinum antitoxin type B, Botulinum B toxin, Botulinum neurotoxin type B precursor, Botulinum toxin type B, BTX-B, RimabotulinumtoxinB, Toxina botulínica B
Type
Weight	150804.0 Da
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Botulinum Neurotoxin Type B Precursor is a purified form of botulinum toxin type B used to block acetylcholine release in the treatment of cervical dystonia and sialorrhea.

For the treatment of patients with cervical dystonia to reduce the severity of abnormal head position and neck pain associated with cervical dystonia.

Botulinum Neurotoxin Type B Precursor is also used to associated treatment for these conditions: Cervical Dystonia, Sialorrhea

How Botulinum Neurotoxin Type B Precursor works

Botulinum Toxin Type B binds to and cleaves the synaptic Vesicle Associated Membrane Protein (VAMP, also known as synaptobrevin) which is a component of the protein complex responsible for docking and fusion of the synaptic vesicle to the presynaptic membrane, a necessary step to neurotransmitter release.

Toxicity

One unit of Botulinum Toxin Type B corresponds to the calculated median lethal intraperitoneal dose (LD50) in mice.

Food Interaction

No interactions found.

Elimination Route

Though pharmacokinetic or ADME studies were not performed, Botulinum Toxin Type B is not expected to be present in the peripheral blood at measurable levels following IM injection at the recommended doses.