Brietal

Brietal Uses, Dosage, Side Effects, Food Interaction and all others data.

An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.

Brietal, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation.

Trade Name Brietal
Availability Prescription only
Generic Methohexital
Methohexital Other Names Methohexital, Methohexitalum, Methohexitone, Metohexital
Related Drugs fentanyl, lidocaine, ketamine, hydromorphone, hyoscyamine, propofol, glycopyrrolate, butorphanol, thiopental
Type
Formula C14H18N2O3
Weight Average: 262.3043
Monoisotopic: 262.131742452
Protein binding

73%

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Brietal
Brietal

Uses

Brietal is an anesthetic used to induce deep sedation.

Brietal is indicated for use as an intravenous anaesthetic. It has also been commonly used to induce deep sedation.

Brietal is also used to associated treatment for these conditions: General Anesthesia, Induction of anesthesia therapy, Sedative therapy

How Brietal works

Brietal binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

Toxicity

The onset of toxicity following an overdose of intravenously administered methohexital will be within seconds of the infusion. If methohexital is administered rectally or is ingested, the onset of toxicity may be delayed. The manifestations of an ultrashort-acting barbiturate in overdose include central nervous system depression, respiratory depression, hypotension, loss of peripheral vascular resistance, and muscular hyperactivity ranging from twitching to convulsive-like movements. Other findings may include convulsions and allergic reactions. Following massive exposure to any barbiturate, pulmonary edema, circulatory collapse with loss of peripheral vascular tone, and cardiac arrest may occur.

Food Interaction

  • Avoid alcohol. Alcohol intake may cause additive CNS depressant effects.

Brietal Alcohol interaction

[Major] GENERALLY AVOID:

Concurrent acute use of barbiturates and ethanol may result in additive CNS effects,

including impaired coordination, sedation, and death.

Tolerance of these agents may occur with chronic use.

The mechanism is related to inhibition of microsomal enzymes acutely and induction of hepatic microsomal enzymes chronically.



The combination of ethanol and barbiturates should be avoided.

Elimination Route

The absolute bioavailability following rectal administration of methohexital is 17%.

Half Life

5.6 ± 2.7 minutes

Elimination Route

Excretion occurs via the kidneys through glomerular filtration.

Innovators Monograph

You find simplified version here Brietal

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000002
http://classyfire.wishartlab.com/tax_nodes/C0001346
http://classyfire.wishartlab.com/tax_nodes/C0000075
http://classyfire.wishartlab.com/tax_nodes/C0000292
http://classyfire.wishartlab.com/tax_nodes/C0002023
http://classyfire.wishartlab.com/tax_nodes/C0002389
http://classyfire.wishartlab.com/tax_nodes/C0003033
http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0000278
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0001831
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:102216
http://www.hmdb.ca/metabolites/HMDB0014617
http://www.genome.jp/dbget-bin/www_bget?drug:D04985
http://www.genome.jp/dbget-bin/www_bget?cpd:C07844
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=9034
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507954
https://www.chemspider.com/Chemical-Structure.8683.html
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=6847
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=102216
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL7413
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000677
http://www.pharmgkb.org/drug/PA164784030
http://www.rxlist.com/cgi/generic3/methohexital.htm
https://www.drugs.com/cdi/methohexital.html
https://en.wikipedia.org/wiki/Methohexital
*** Taking medicines without doctor's advice can cause long-term problems.
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