Bromazinum
Bromazinum Uses, Dosage, Side Effects, Food Interaction and all others data.
Bromazinum is an ethanolamine antihistamine with antimicrobial property. Bromazinum is used in the control of cutaneous allergies. Ethanolamine antihistamines produce marked sedation in most patients.
Bromazinum is an antihistamine of the ethanolamine class. Ethanolamine antihistamines have significant antimuscarinic activity and produce marked sedation in most patients. In addition to the usual allergic symptoms, the drug also treats irritant cough and nausea, vomiting, and vertigo associated with motion sickness. It also is used commonly to treat drug-induced extrapyramidal symptoms as well as to treat mild cases of Parkinson's disease. Rather than preventing the release of histamine, as do cromolyn and nedocromil, Bromazinum competes with free histamine for binding at HA-receptor sites. Bromazinum competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Ethanolamine derivatives have greater anticholinergic activity than do other antihistamines, which probably accounts for the antidyskinetic action of Bromazinum. This anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown.
Trade Name | Bromazinum |
Generic | Bromodiphenhydramine |
Bromodiphenhydramine Other Names | Bromazina, Bromazine, Bromazinum |
Type | |
Formula | C17H20BrNO |
Weight | Average: 334.251 Monoisotopic: 333.072826914 |
Protein binding | 96% |
Groups | Approved |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
For management of symptoms related to hay fever and other types of allergy and used to help bring up phlegm, thin secretions, and make a cough productive.
How Bromazinum works
Bromazinum competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding.
Toxicity
Signs of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, swelling of face, lips, tongue, or throat.
Food Interaction
No interactions found.Elimination Route
Well absorbed in the digestive tract.
Half Life
1 to 4 hours
Innovators Monograph
You find simplified version here Bromazinum