Carboxymethylcellulose Sodium + Hypromellose
Carboxymethylcellulose Sodium + Hypromellose Uses, Dosage, Side Effects, Food Interaction and all others data.
Each ml of Carboxymethylcellulose Sodium sterile eye gel drops contains: Active Substance: Carboxymethylcellulose Sodium USP 10 mg. Preservative: Purite 0.0075%Hydroxypropyl methylcellulose belongs to the group of medicines known as artificial tears. It is used to relieve dryness and irritation caused by reduced tear flow. It helps prevent damage to the eye in certain eye diseases. Hydroxypropyl methylcellulose may also be used to moisten hard contact lenses and artificial eyes. In addition, it may be used in certain eye examinations.
Hypromellose is the most commonly used in hydrophilic matrix fabrication. It allows for controlled release of drug substances, increasing duration of therapeutic effects . The physical characteristics of this drug resemble natural tears, providing lubrication to the ocular surface and maintaining corneal hydration in dry eye syndromes .
Hypromellose is considered an inert substance as it has no direct pharmacological activity. The viscosity promoting properties of hypromellose prolong the retention time and improve adhesion of synthetic tears to the cornea and conjunctiva. As a result, the tear film breakdown time is prolonged and/or the tear film stability is enhanced. A stable tear film protects the cornea from dryness and epithelial cells .
Hypromellose is a methyl and hydroxypropyl mixed ether of cellulose. It is utilized as artificial tears to prevent conjunctival and corneal damage due to impaired lacrimal secretions. It is also used as a visco-elastic promoting agent by maintaining a deep, viscous chamber and allowing for easier manipulation, helping the vitreous surface to be pushed back, thus preventing the formation of a postoperative flat chamber .
| Trade Name | Carboxymethylcellulose Sodium + Hypromellose |
| Generic | Carboxymethylcellulose Sodium + Hypromellose |
| Type | |
| Therapeutic Class | Drugs for Dry eyes |
| Manufacturer | |
| Available Country | Bangladesh |
| Last Updated: | September 24, 2024 at 5:38 am |
Uses
This medication is used to relieve the dryness and pain associated with reduced or abnormal tear production.Carboxymethylcellulose Sodium + Hypromellose is also used to associated treatment for these conditions: Dry Eyes, Ocular Discomfort, Ocular Irritation
How Carboxymethylcellulose Sodium + Hypromellose works
Promotes corneal wetting by the stabilization and thickening the precorneal tear film and prolonging the tear film breakdown time, which is usually shortened in dry eye conditions. Hypromellose also acts to lubricate and protect the eye .
The surface active properties of the vehicles found in artificial tears solutions act to stabilize the tear film and increase tear viscosity to prevent delay tear evaporation and delay tear drainage .
In the intact eye, the corneal surface is moistened primarily by the mucin that is produced in the conjunctiva. Mucin is adsorbed on the corneal surface and forms a hydrophilic surface. This creates a moisture barrier. In the typical dry eye, and particularly in case of mucin deficiency, the application of artificial tear fluid is highly recommended. Both its surface activity and its adsorptive capacity make hypromellose optimal for this use. Hypromellose has a physical-chemical action and leads to, in an aqueous solution, a reduced surface tension as well as an increased level of viscosity. Hypromellose adheres well to the cornea and conjunctiva and provides ample moisture. Irritation symptoms caused by blinking, which occur in the case of tear fluid deficiency, are therefore decreased and symptoms of epithelial desiccation are also alleviated .
Dosage
Carboxymethylcellulose Sodium + Hypromellose dosage
For Adults and Children: Instill 1 or 2 drops in the affected eye(s) as needed.Side Effects
Common side effects are blurred vision, matting or stickiness of eyelashes.Toxicity
LD 50 (Rat): > 5 g/kg .
Hypromellose is considered low toxicity to non-toxic .
Adverse events may include blurred vision and contact dermatitis . Hypersensitivity and intolerance reactions may occur (for example, eye burning, pain, increased lacrimation, a sensation of foreign body, conjunctival hyperemia, eyelid swelling, pruritus). The stickiness sensation of the eyelids, the decreased sense of smell, photosensitivity .
Precaution
If you experience eye pain, changes in vision, continued redness or irritation of the eye or if your symptoms continue for more than 3 days or become worse, check with your doctor.Interaction
If several medicines are to be administered to the eye, there should be an interval of at least 5 minutes between each application.Hypromellose can be used in combination with contact lenses. No compatibility study with lens material is available.
Elimination Route
Not systemically absorbed .
Pregnancy & Breastfeeding use
Carboxymethylcellulose Sodium & Hypromellose have not been shown to cause birth defects or other problems during pregnancy and breastfeeding.Contraindication
Known sensitivity or allergy to any ingredient of the formulation.Special Warning
This drug does not cause different side effects or problems in children than it does in adults.Acute Overdose
No case of overdose has been reported.
Storage Condition
Store in a cool, dry place and protected from light, Keep out of the reach of children, Do not use more than 4 weeks after opening.Innovators Monograph
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