Cefthan-DS

Cefthan-DS Uses, Dosage, Side Effects, Food Interaction and all others data.

Cefthan-DS is an orally available cephalosporin antibiotic. As part of its drug class, it shares structural properties to cefalexin as well as its activity spectrum. It was used in Italy but has since been withdrawn.

Cefthan-DS is a cephalosporin antibiotic which produces a bactericidal effect on susceptible bacteria .

Trade Name Cefthan-DS
Generic Cefroxadine
Cefroxadine Other Names Cefroxadine, cefroxadino
Type
Formula C16H19N3O5S
Weight Average: 365.4
Monoisotopic: 365.104541898
Protein binding

Cefrixadine is 10% bound to human plasma proteins .

Groups Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Cefthan-DS
Cefthan-DS

Uses

Was used for the treatment of bacterial infections.

How Cefthan-DS works

Cefrixadine is a cephalosporin antibiotic, a class of β-lactam antibiotics similar to penicillins, which binds to and inhibits penicillin binding proteins (PBPs) . PBPs are responsible for catalyzing the transpeptidase reaction which cross-links the peptide side chains on the sugar residues of a peptidoglycan unit, adding the unit to the peptidoglycan layer. This disrupts the balance between the hydrolysis of peptidoglycan, in order to insert new peptidoglycan units, by murein hydrolase and the attachment of the new units which leads to overall destruction of the peptidoglycan layer. With the loss of its peptidoglycan layer the cell also loses its resistance to the high osmotic pressure inside its membrane and lyses.

Volume of Distribution

Volume of distrubution of 15 L .

Elimination Route

Oral bioavailability of 90% .

Half Life

The serum half life is 0.9-1.1 h .

Clearance

The total body clearance is 340 mL/min and the renal clearance is 250 mL/min .

Elimination Route

Primarily eliminated in the urine (80-96%) .

Innovators Monograph

You find simplified version here Cefthan-DS

*** Taking medicines without doctor's advice can cause long-term problems.
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