Ceftizoxima
Ceftizoxima Uses, Dosage, Side Effects, Food Interaction and all others data.
A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.
Ceftizoxima is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.
Trade Name | Ceftizoxima |
Availability | Discontinued |
Generic | Ceftizoxime |
Ceftizoxime Other Names | Ceftizoxima, Ceftizoxime, Ceftizoximum |
Related Drugs | amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin, Augmentin |
Type | |
Formula | C13H13N5O5S2 |
Weight | Average: 383.403 Monoisotopic: 383.035809931 |
Protein binding | 30% protein-bound across the standard concentration range. |
Groups | Approved, Withdrawn |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Ceftizoxima is a third-generation cephalosporin antibiotic used in the treatment of various bacterial infections, including lower respiratory tract infection, urinary tract infection, and gonorrhea.
Cetizoxime was previously indicated for the treatment of infections due to susceptible strains of bacteria.
Ceftizoxima is also used to associated treatment for these conditions: Bacterial Infections
How Ceftizoxima works
Ceftizoxima is an aminothiazolyl cephalosporin with an extended spectrum of activity against many gram-negative, nosocomially acquired pathogens. It has excellent beta-lactamase stability, with good in vitro activity against Haemophilus influenzae, Neisseria gonorrhoeae and Klebsiella pneumoniae. Ceftizoxima, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that ceftizoxime interferes with an autolysin inhibitor.
Food Interaction
No interactions found.Ceftizoxima Hypertension interaction
[Moderate] Parenteral ceftizoxime sodium contains approximately 60 mg (2.6 mEq) of sodium per each gram of ceftizoxime activity.
The sodium content should be considered in patients with conditions that may require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.
Ceftizoxima Drug Interaction
Unknown: aspirin, aspirin, epinephrine, epinephrine, calcium / vitamin d, calcium / vitamin d, Allergy , Allergy , sulfamethoxazole / trimethoprim, sulfamethoxazole / trimethoprim, meperidine, meperidine, ginkgo, ginkgo, acetaminophen, acetaminophen, valproic acid, valproic acid, multivitamin, multivitamin
Ceftizoxima Disease Interaction
Major: colitisModerate: renal dysfunction, sodium, dialysis, liver disease, seizure disorders
Volume of Distribution
The mean apparent volume of distribution ranges between 15 - 28L.
Elimination Route
Excreted virtually unchanged by the kidneys in 24 hours.
Innovators Monograph
You find simplified version here Ceftizoxima