Cephalothin
Cephalothin Uses, Dosage, Side Effects, Food Interaction and all others data.
Cephalothin is a cephalosporin antibiotic.
Cephalothin (INN) or cephalothin (USAN) is a semisynthetic first generation cephalosporin having a broad spectrum of antibiotic activity that is administered parenterally.
Trade Name | Cephalothin |
Generic | Cefalotin |
Cefalotin Other Names | Cefalothin, Cefalotin, Cefalotina, CĂ©falotine, Cefalotinum, Cephalothin, Cephalotin |
Type | |
Formula | C16H16N2O6S2 |
Weight | Average: 396.438 Monoisotopic: 396.044977634 |
Protein binding | 65-80% |
Groups | Approved, Investigational, Vet approved |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Cephalothin is a broad-spectrum cephalosporin antibiotic used for the treatment of serious bacterial infections in various locations, such as the urinary tract, skin, bone, and lower respiratory tract.
Used to prevent infection during surgery and to treat many kinds of infections of the blood, bone or joints, respiratory tract, skin, and urinary tract.
Cephalothin is also used to associated treatment for these conditions: Susceptible Bacterial Infections
How Cephalothin works
The bactericidal activity of cefalotin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). The PBPs are transpeptidases which are vital in peptidoglycan biosynthesis. Therefore, their inhibition prevents this vital cell wall compenent from being properly synthesized.
Toxicity
Rat intravenous LD50 is 4000 mg/kg.
Food Interaction
No interactions found.Half Life
30 minutes
Innovators Monograph
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