Clomethiazolum

Clomethiazolum Uses, Dosage, Side Effects, Food Interaction and all others data.

Clomethiazolum is a well-established γ-aminobutyric acid (GABAA)-mimetic drug. It is a sedative and hypnotic that is widely used in treating and preventing symptoms of acute alcohol withdrawal. It is a drug which is structurally related to thiamine (vitamin B1) but acts like a sedative, hypnotic, muscle relaxant and anticonvulsant. It is also used for the management of agitation, restlessness, short-term insomnia and Parkinson's disease in the elderly.

Trade Name Clomethiazolum
Generic Clomethiazole
Clomethiazole Other Names Clomethiazole, Clomethiazolum, Clometiazol
Type
Formula C6H8ClNS
Weight Average: 161.65
Monoisotopic: 161.0065981
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Clomethiazolum
Clomethiazolum

Uses

Investigated for use/treatment in strokes.

How Clomethiazolum works

clomethiazole interacts with the GABAA receptor complex. It inhibits the binding of [35S]butyl-bicyclophosphorothionate (TBPS), an effect indicative of GABAA receptor-channel activation, by increasing the rate of [35S]TBPS dissociation and decreasing the binding affinity. Gamma-aminobutyric acid (GABA), acting at GABAA receptors, is the main fast inhibitory neurotransmitter in mammalian central nervous system

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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