Clomociclina
Clomociclina Uses, Dosage, Side Effects, Food Interaction and all others data.
Clomociclina is a tetracycline used to treat bacterial infections.
Clomociclina is a tetracycline antibiotic that is commonly prescribed by medical doctors for infections and to treat acne. It may also be used to treat urinary tract infections, gum disease, and other bacterial infections such as gonorrhea and chlamydia. Clomociclina is also used commonly as a prophylactic treatment for infection by Bacillus anthracis (anthrax). It is also effective against Yersinia pestis and malaria and is also prescribed for the treatment of Lyme disease. Clomociclina inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Cells become resistant to Clomociclina by at least two mechanisms: efflux and ribosomal protection. In efflux, a resistance gene encodes a membrane protein that actively pumps Clomociclina out of the cell. This is the mechanism of action of the tetracycline resistance gene on the artificial plasmid pBR322. In ribosomal protection, a resistance gene encodes a protein which binds to the ribosome and prevents Clomociclina from acting on the ribosome.
| Trade Name | Clomociclina |
| Generic | Clomocycline |
| Clomocycline Other Names | Chlormethylenecycline, Clomociclina, Clomocyclina, Clomocycline, Clomocyclinum |
| Type | |
| Formula | C23H25ClN2O9 |
| Weight | Average: 508.906 Monoisotopic: 508.124858115 |
| Groups | Experimental |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the treatment and management of Brucellosis, mycoplasma infection, acne vulgaris, chlamydial infection;Chronic bronchitis
How Clomociclina works
Clomociclina inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Clomociclina is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane.
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