Coagulation Factor IX (human)

Coagulation Factor IX (human) Uses, Dosage, Side Effects, Food Interaction and all others data.

Factor IX (or Christmas factor) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes hemophilia B.

Binds vitamin K and factor VIIIa. Cleaves the Arg-Ile bond in factor X to form active factor Xa. Plays a key role in blood coagulation and clotting. Injections of factor IX are used to treat hemophilia B, which is sometimes called Christmas disease. AlphaNine is injected to increase plasma levels of Factor IX and can temporarily correct this coagulation defect. The activated partial thromboplastin time (aPTT) is prolonged in people with hemophilia B. Treatment with factor IX concentrate may normalize the aPTT by temporarily replacing the factor IX. The administration of BeneFIX increases plasma levels of factor IX, and can temporarily correct the coagulation defect in these patients.

Coagulation Factor IX (human)
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Trade Name	Coagulation Factor IX (human)
Generic	Coagulation Factor IX Human
Coagulation Factor IX Human Other Names	Antihemophilic factor B, Coagulation factor IX (human), Factor IX (Human), Factor IX purificado, Human coagulation factor IX
Type
Formula	C₂₀₄₁H₃₁₃₆N₅₅₈O₆₄₁S₂₅
Weight	46548.2 Da
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Coagulation Factor IX (human) is a coagulation factor used to treat hemophilia B or factor IX hemophilia.

Factor IX is used to treat Christmas disease. Factor IX deficiency is treated by injection factor IX produced from human plasma. Tranexamic acid may be of value in patients undergoing surgery who have inherited factor IX deficiency in order to reduce the perioperative risk of bleeding.

Coagulation Factor IX (human) is also used to associated treatment for these conditions: Acquired Coagulation Factor Deficiency, Bleeding caused by Hemophilia B, Major Bleeding, Vitamin K antagonist induced major bleeding

How Coagulation Factor IX (human) works

Coagulation Factor IX is an important protein in the process of hemostasis and normal blood clotting as it plays a key role within the coagulation cascade. It is located within the blood plasma as a zymogen, an antecedent to enzymatic function, in its inactivated state. Factor IX is dependent on the presence of Vitamin K, and is activated to a serine protease by the function of Coagulation Factor XIa. Factor XIa cleaves the peptide bond associated with protein activation in Factor IX, leaving Factor IX with two exposed chains, a light chain and a heavy chain. These two chains are held together by several disulfide bonds that reinforce the structure of Factor IX's activated form. After being activated, Factor IX forms a complex with calcium ions, membrane phospholipids and Coagulation Factor VIII to activate Coagulation Factor X. The activation of Factor X then performs a similarly integral step in the blood coagulation cascade. The ultimate result of phenotypically normal coagulation factors is the creation of platelets for normal blood clotting.