P-Chlorophenol
P-Chlorophenol Uses, Dosage, Side Effects, Food Interaction and all others data.
P-chlorophenol is a white crystals with a strong phenol odor. Slightly soluble to soluble in water, depending on the isomer, and denser than water. Noncombustible.
| Trade Name | P-Chlorophenol |
| Generic | Parachlorophenol |
| Parachlorophenol Other Names | 4-Chlorophenol, 4-chlorphenol, p-Chlorophenol, Parachlorophenol |
| Type | |
| Formula | C6H5ClO |
| Weight | Average: 128.556 Monoisotopic: 128.002892489 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
P-Chlorophenol is an antibacterial agent used to prevent infections in root canals.
Used as an intermediate in organic synthesis of dyes and drugs. Local antibacterial agent in root canal therapy, as topical antiseptic in ointments
P-Chlorophenol is also used to associated treatment for these conditions: Root Canal Disinfection
How P-Chlorophenol works
The major mode of action of chlorophenols appears to be the uncoupling of oxidative phosphorylation. The strength of the uncoupling effect is related to the degree of chlorination: PCP is the strongest inhibitor of oxidative phosphorylation, MCP the weakest. To a lesser extent, inhibition of oxidative phosphorylation is affected by the positions of the chlorine atoms on the molecule.
Toxicity
Signs and symptoms in human : When undiluted, it whitens & cauterizes the skin & mucous membranes. 4-chlorophenol was shown to permeate the skin. It produces damage at a threshold concentration of 0.75% (w/v).
Routes of Entry: Absorbed through skin. Eye contact. Toxicity to Animals: Acute oral toxicity (LD50): 367 mg/kg [Mouse]. Acute dermal toxicity (LD50): 1500 mg/kg [Rat]. Chronic Effects on Humans: CARCINOGENIC EFFECTS: Classified 2B (Possible for human.) by IARC. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/male, Development toxin [POSSIBLE]. May cause damage to the following organs: liver, brain, gastrointestinal tract, upper respiratory tract, central nervous system (CNS). Other Toxic Effects on Humans: Very hazardous in case of skin contact (irritant).
Food Interaction
No interactions found.Elimination Route
absorbed from gastrointestinal tract.
Elimination Route
87% of 4-chlorophenol was excreted in urine of dogs as sulfate and glucuronide.
Innovators Monograph
You find simplified version here P-Chlorophenol
