P-Chlorophenol

P-Chlorophenol Uses, Dosage, Side Effects, Food Interaction and all others data.

P-chlorophenol is a white crystals with a strong phenol odor. Slightly soluble to soluble in water, depending on the isomer, and denser than water. Noncombustible.

Trade Name P-Chlorophenol
Generic Parachlorophenol
Parachlorophenol Other Names 4-Chlorophenol, 4-chlorphenol, p-Chlorophenol, Parachlorophenol
Type
Formula C6H5ClO
Weight Average: 128.556
Monoisotopic: 128.002892489
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
P-Chlorophenol
P-Chlorophenol

Uses

P-Chlorophenol is an antibacterial agent used to prevent infections in root canals.

Used as an intermediate in organic synthesis of dyes and drugs. Local antibacterial agent in root canal therapy, as topical antiseptic in ointments

P-Chlorophenol is also used to associated treatment for these conditions: Root Canal Disinfection

How P-Chlorophenol works

The major mode of action of chlorophenols appears to be the uncoupling of oxidative phosphorylation. The strength of the uncoupling effect is related to the degree of chlorination: PCP is the strongest inhibitor of oxidative phosphorylation, MCP the weakest. To a lesser extent, inhibition of oxidative phosphorylation is affected by the positions of the chlorine atoms on the molecule.

Toxicity

Signs and symptoms in human : When undiluted, it whitens & cauterizes the skin & mucous membranes. 4-chlorophenol was shown to permeate the skin. It produces damage at a threshold concentration of 0.75% (w/v).

Routes of Entry: Absorbed through skin. Eye contact. Toxicity to Animals: Acute oral toxicity (LD50): 367 mg/kg [Mouse]. Acute dermal toxicity (LD50): 1500 mg/kg [Rat]. Chronic Effects on Humans: CARCINOGENIC EFFECTS: Classified 2B (Possible for human.) by IARC. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/male, Development toxin [POSSIBLE]. May cause damage to the following organs: liver, brain, gastrointestinal tract, upper respiratory tract, central nervous system (CNS). Other Toxic Effects on Humans: Very hazardous in case of skin contact (irritant).

Food Interaction

No interactions found.

Elimination Route

absorbed from gastrointestinal tract.

Elimination Route

87% of 4-chlorophenol was excreted in urine of dogs as sulfate and glucuronide.

Innovators Monograph

You find simplified version here P-Chlorophenol

*** Taking medicines without doctor's advice can cause long-term problems.
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