Coccidioides immitis spherule

Coccidioides immitis spherule Uses, Dosage, Side Effects, Food Interaction and all others data.

Coccidioides immitis spherule is a skin test antigen indicated to detect delayed-type hypersensitivity to Coccidioides immitis in individuals with a history of pulmonary coccidioidomycosis.

Illicit cellular immune response if patient has been exposed to Coccidiodes immitis.

Table Of contents

• Coccidioides immitis spherule
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Coccidioides immitis spherule
Generic	Coccidioides immitis spherule
Type
Protein binding	Not absorbed systemically.
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Coccidioides immitis spherule is a skin antigen test for delayed-type hypersensitivity to Coccidioides immitis.

Indicated to detect delayed-type hypersensitivity to Coccidioides immitis in individuals with a history of pulmonary coccidioidomycosis. Use in 18-64 year old patients. A positive result occurs if 48h after administration if the diameter of the induration is >5mm.

Coccidioides immitis spherule is also used to associated treatment for these conditions: Delayed-type hypersensitivity to Coccidioides immitis

How Coccidioides immitis spherule works

Delayed type hypersensitivity reaction begin with the C.immitis antigen is presented to CD4 and CD8 lymphocytes by antigen presenting cells. This causes the secretion of interleukins and other lymphokines from macrophage cells. The release of effector molecules causes blood vessels to become permeable and allows fibrinogen to escape into the surrounding tissue where it is converted to fibrin. The deposition of fibrin and the movement of T-cells and monocytes in the extracellular spaces cause the tissue to become indurated. The induration is usually detectable in 18 hours and peaks at 48 hours.

Toxicity

Systemic hypersensitivity reaction may be life threatening.

Volume of Distribution

Not absorbed systemically.

Elimination Route

Not absorbed. Given intradermally for local effect.

Elimination Route

Eliminated via cellular immune response.

Innovators Monograph

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