Corticorelin Triflutate
Corticorelin Triflutate Uses, Dosage, Side Effects, Food Interaction and all others data.
Corticorelin, available commercially as corticorelin ovine triflutate (tradename Acthrel), is a synthetic form of the peptide human corticotropin-releasing hormone (hCRH), a potent stimulator of adrenocorticotropic hormone (ACTH) release from the anterior pituitary. Endogenous forms hCRH are involved in the stress response and its main function is stimulation of the pituitary to release ACTH.
It is used as a diagnostic agent to evaluate the status of the pituitary-adrenal axis in the differentiation of a pituitary source from an ectopic source of excessive ACTH secretion. It provides a differential diagnosis for Cushing's disease (a pituitary source of ACTH excess) or of ectopic ACTH syndrome (an ectopic source of ACTH excess). If corticorelin injection results in an increase of plasma ACTH and cortisol, the patient is diagnosed with Cushing's disease. However, if corticorelin injection does not result in an increase of plasma ACTH and cortisol, the patient is diagnosed with ectopic ACTH syndrome.
In normal subjects, intravenous administration of corticorelin results in a rapid and sustained increase of plasma ACTH levels and a near parallel increase of plasma cortisol. In addition, intravenous administration of corticorelin to normal subjects causes a concomitant and prolonged release of the related proopiomelanocortin peptides β- and γ-lipotropins (β -and γ-LPH) and β-endorphin (β -END).
Trade Name | Corticorelin Triflutate |
Generic | Corticorelin ovine triflutate |
Corticorelin ovine triflutate Other Names | Corticorelin ovine, Corticorelin ovine triflutate, Corticorelin triflutate, Corticotropin-releasing factor (sheep hypothalamus), Corticotropin-releasing factor (sheep), Ovine ACTH releasing factor, Ovine corticotropin-releasing factor, Ovine CRF 41, Ovine CRH, Sheep corticotropin-releasing factor, Sheep corticotropin-releasing factor (1-41) |
Type | |
Formula | C205H339N59O63S |
Weight | Average: 4670.38 Monoisotopic: 4667.485744386 |
Protein binding | Corticorelin does not appear to be bound specifically by a circulating plasma protein. |
Groups | Approved |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Corticorelin Triflutate is a synthetic corticotropin-releasing hormone used for diagnostic purposes in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome.
Corticorelin is indicated for use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome.
Corticorelin Triflutate is also used to associated treatment for these conditions: Pituitary-dependent Cushing's syndrome
How Corticorelin Triflutate works
Corticorelin is a potent stimulator of adrenocorticotropic hormone (ACTH) release from the anterior pituitary. It is used as a diagnostic agent to evaluate the status of the pituitary-adrenal axis in the differentiation of a pituitary source from an ectopic source of excessive ACTH secretion.
Toxicity
The severity of adverse effects to a corticorelin injection appear to be dose-dependent. Dosages above 1 mcg/kg are not recommended. While few adverse effects have been observed at the 1 mcg/kg or 100 mcg dose, higher doses have been associated with transient tachycardia, decreased blood pressure, loss of consciousness, and asystole.
Food Interaction
No interactions found.Volume of Distribution
The mean volume of distribution for IR-corticorelin is 6.2 ± 0.5 L
Elimination Route
Plasma ACTH levels in normal subjects increased 2 minutes after injection of corticorelin doses of ≥0.3 mcg/kg and reached peak levels after 10-15 minutes. Plasma cortisol levels increased within 10 minutes and reached peak levels at 30 to 60 minutes.
Half Life
Plasma half-lives for IR-corticorelin are 11.6 ± 1.5 minutes (mean ± SE) for the fast component and 73 ± 8 minutes for the slow component.
Clearance
95 ± 11 L/m2/day
Innovators Monograph
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