Cosmegen
Cosmegen Uses, Dosage, Side Effects, Food Interaction and all others data.
A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
Generally, the actinomycins exert an inhibitory effect on gram-positive and gram-negative bacteria and on some fungi. However, the toxic properties of the actinomycins (including dactinomycin) in relation to antibacterial activity are such as to preclude their use as antibiotics in the treatment of infectious diseases. Because the actinomycins are cytotoxic, they have an antineoplastic effect which has been demonstrated in experimental animals with various types of tumor implant. This cytotoxic action is the basis for their use in the treatment of certain types of cancer. Cosmegen is believed to produce its cytotoxic effects by binding DNA and inhibiting RNA synthesis.
Trade Name | Cosmegen |
Availability | Prescription only |
Generic | Dactinomycin |
Dactinomycin Other Names | ActD, Actinomycin C1, Actinomycin D, Actinomycin IV, Dactinomicina, Dactinomycin, Dactinomycine, Dactinomycinum, Meractinomycin |
Related Drugs | aspirin, prednisone, ibuprofen, meloxicam, naproxen, Cymbalta, methotrexate, carboplatin, fluorouracil, doxorubicin |
Weight | 0.5mg, |
Type | Injection, Intravenous Powder For Injection |
Formula | C62H86N12O16 |
Weight | Average: 1255.417 Monoisotopic: 1254.628474764 |
Protein binding | 5% |
Groups | Approved, Investigational |
Therapeutic Class | |
Manufacturer | A,menarini India |
Available Country | Canada, India, United States, |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Cosmegen is an actinomycin used to treat a wide variety of cancers.
For the treatment of Wilms' tumor, childhood rhabdomyosarcoma, Ewing's sarcoma and metastatic, nonseminomatous testicular cancer as part of a combination chemotherapy and/or multi-modality treatment regimen
Cosmegen is also used to associated treatment for these conditions: Ewing's Sarcoma, Gestational Trophoblastic Disease, Ovarian Cancer, Rhabdomyosarcomas, Sarcoma, Osteogenic, Wilms' tumor, Metastatic nonseminomatous Testicular cancer
How Cosmegen works
Good evidence exists that this drug bind strongly, but reversibly, to DNA, interfering with synthesis of RNA (prevention of RNA polymerase elongation) and, consequently, with protein synthesis.
Toxicity
hepatoxicity
Food Interaction
No interactions found.Cosmegen Drug Interaction
Unknown: amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, epinephrine, epinephrine, amoxicillin, amoxicillin, RHO Immunoglobulin , RHO Immunoglobulin , darbepoetin alfa, darbepoetin alfa, mesalamine, mesalamine, lorazepam, lorazepam, sulfamethoxazole / trimethoprim, sulfamethoxazole / trimethoprim, citalopram, citalopram, ondansetron, ondansetron
Cosmegen Disease Interaction
Major: infectionsModerate: hepatic toxicity, live viral vaccines, myelosuppression, renal toxicity
Elimination Route
poorly absorbed from gastrointestinal tract
Half Life
36 hours
Innovators Monograph
You find simplified version here Cosmegen