Cyclaine

Cyclaine Uses, Dosage, Side Effects, Food Interaction and all others data.

Cyclaine hydrochloride is also known as cyclaine and osmocaine. It is a short acting local anesthetic that acts through inhibition of sodium channels. Patients experience an overdose may present with headache, tinnitus, numbness and tingling around the mouth and tongue, convulsions, inability to breathe, and decreased heart function. Cyclaine has been discontinued in the US market.

Cyclaine is a local ester-class anesthetic. Local anesthetics produce a transient block of nerve conduction by interfering with sodium channels. This effect of the anesthetic interferes with the development of an action potential across the nerve.

Trade Name Cyclaine
Generic Hexylcaine
Hexylcaine Other Names Hexilcaina, Hexylcaine, Hexylcainum
Type
Formula C16H23NO2
Weight Average: 261.3593
Monoisotopic: 261.172878985
Groups Approved, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Cyclaine
Cyclaine

Uses

Used as a local anesthetic for surface application, infiltration or nerve block

How Cyclaine works

Hexyl caine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel.

Toxicity

Symptoms of anesthetic overdose include headache, tinnitus, circumoral and tongue paresthesias, restlessness, talkativeness, facial twitching, convulsions, respiratory arrest, and cardiac depression

Half Life

<10 minutes

Innovators Monograph

You find simplified version here Cyclaine

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http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:34791
http://www.hmdb.ca/metabolites/HMDB0014616
http://www.genome.jp/dbget-bin/www_bget?cpd:C14172
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=10770
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506241
https://www.chemspider.com/Chemical-Structure.10315.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225698
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=26879
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=34791
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1197
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000506
http://www.pharmgkb.org/drug/PA164746489
https://en.wikipedia.org/wiki/Hexylcaine
*** Taking medicines without doctor's advice can cause long-term problems.
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