D-Norgestrel 3-oxime
D-Norgestrel 3-oxime Uses, Dosage, Side Effects, Food Interaction and all others data.
D-Norgestrel 3-oxime is a drug used in contraception. D-Norgestrel 3-oxime is the active progestin responsible for the progestational activity that occurs in women after application of ORTHO EVRA patch.
D-Norgestrel 3-oxime is used for contraception and menopausal hormonal therapy transdermally or in combination with ethinyl estradiol as a vaginal ring. D-Norgestrel 3-oxime, in combination with ethinyl estradiol inhibits ovulation by suppressing gonadotropins.
Trade Name | D-Norgestrel 3-oxime |
Generic | Norelgestromin |
Norelgestromin Other Names | 17-Deacetylnorgestimate, 17-Deacylnorgestimate, D-Norgestrel 3-oxime, Deacetylnorgestimate, Levonorgestrel 3-oxime, Levonorgestrel oxime, Norelgestromin, Norelgestromina, Norplant 3-oxime |
Type | |
Formula | C21H29NO2 |
Weight | Average: 327.468 Monoisotopic: 327.219829178 |
Groups | Approved, Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
D-Norgestrel 3-oxime is a progestin used for the prevention of pregnancy in women who elect to use a transdermal patch as a method of contraception.
D-Norgestrel 3-oxime is used for contraception and menopausal hormonal therapy. D-Norgestrel 3-oxime may potentially be used in breast cancer treatment due to its inhibitory effect on estrone sulfatase . They convert sulfated steroid precursors to estrogen during pregnancy.
D-Norgestrel 3-oxime is also used to associated treatment for these conditions: Polycystic Ovarian Syndrome, Transdermal contraception therapy
How D-Norgestrel 3-oxime works
D-Norgestrel 3-oxime inhibits estrone sulfatase, which converts sulfated steroid precursors to estrogen during pregnancy. Norgelgestromin/ethinylestradiol suppresses follicular development, induces changes to the endometrium, which decreases chances of implantation and thickens the cervical mucus, impeding sperm swimming into the uterus. It also has similar agonisting binding affinities as its parent compound, Norgestimate, for progesterone and estrogen receptors.
Food Interaction
No interactions found.Innovators Monograph
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