Daivonex

Daivonex Uses, Dosage, Side Effects, Food Interaction and all others data.

In humans, natural supply of vitamin D depends mainly on exposure to the ultraviolet rays of the sun for conversion of 7-dehydrocholesterol to vitamin D3 (cholecalciferol) in the skin. Daivonex is a synthetic analog of vitamin D3. Daivonex regulates skin cell production and development, thereby modifying the abnormal growth and production of keratinocytes, responsible for the plaque psoriasis.

Calcipotriene is a synthetic analog of vitamin D. In humans, the natural supply of vitamin D depends mainly on exposure to the ultraviolet rays of the sun for conversion of 7-dehydrocholesterol to vitamin D3 (cholecalciferol) in the skin.

Trade Name Daivonex
Generic Calcipotriol
Calcipotriol Other Names Calcipotriene, Calcipotriol
Weight 05%w/w, 50mcg/gm, 50mcg/ml,
Type Scalp Lotion, Ointment, Cream, Scalp Solution
Formula C27H40O3
Weight Average: 412.6047
Monoisotopic: 412.297745146
Groups Approved
Therapeutic Class Topical Vitamin D & related preparations
Manufacturer Win-medicare Pvt Ltd, Zam Zam Corporation, Squibb, Kapricorn
Available Country India, Pakistan, Bangladesh,
Last Updated: September 19, 2023 at 7:00 am
Daivonex
Daivonex

Uses

Daivonex ointment is used for the treatment of plaque psoriasis in adults.

Daivonex is also used to associated treatment for these conditions: Plaque psoriasis of the scalp, Psoriasis Vulgaris (Plaque Psoriasis)

How Daivonex works

The precise mechanism of calcipotriol in remitting psoriasis is not well-understood, however, it has been shown to have comparable affinity with calcitriol for the Vitamin D receptor while being less than 1% the activity in regulating calcium metabolism. The Vitamin D receptor (VDR) belongs to the steroid/thyroid receptor superfamily, and is found on the cells of many different tissues including the thyroid, bone, kindney, and T cells of the immune system. T cells are known to play a role in psoriasis and are believed to undergo modulation of gene expression with binding of calcipotriol to the VDR. This modulation is thought to affect gene products related to cell differentiation and proliferation.

Dosage

Daivonex dosage

A thin layer of Daivonex ointment once or twice daily and rub in gently and completely. The maximum recommanded weekly dose of Daivonex ointment is 100 gm/week.Pediatric use: Safety and effectiveness of Daivonex ointment in pediatric patients have not been established.

Side Effects

The most frequent adverse experiences reported for Daivonex ointment were cases of skin irritation, which occurred in approximately 10-15% of patients. Rash, pruritus, dermatitis and worsening of psoriasis were reported in 1 to 10% of patients. Other experiences reported in less than 1% of patients included skin atrophy, hyperpigmentation, hypercalcemia, and folliculitis.

Toxicity

Topically applied calcipotriene can be absorbed in sufficient amounts to produce systemic effects. Elevated serum calcium has been observed with excessive use of calcipotriene.

Precaution

Use of Daivonex ointment may cause irritation of lesions and surrounding uninvolved skin. If irritation develops, Daivonex ointment should be discontinued.Transient, rapidly reversible elevation of serum calcium has occurred with use of Daivonex ointment. If elevation in serum calcium outside the normal range occurs, discontinue treatment until normal calcium levels are restored.

Food Interaction

No interactions found.

Elimination Route

Clinical studies with radiolabeled ointment indicate that approximately 6% (+3%, SD) of the applied dose of calcipotriene is absorbed systemically when the ointment is applied topically to psoriasis plaques or 5% (+2.6%, SO) when applied to normal skin.

Elimination Route

The active form of the vitamin, 1,25-dihydroxy vitamin D3 (calcitriol), is known to be recycled via the liver and excreted in the bile. There is evidence that maternal 1,25-dihydroxy vitamin D3 (calcitriol) may enter the fetal circulation, but it is not known whether it is excreted in human milk.

Pregnancy & Breastfeeding use

Use in pregnancy: There are no adequate and well-controlled studies in pregnant women. Therefore, Daivonex ointment should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Use in lactation: It is not known whether Daivonex is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Daivonex ointment is administered to a nursing woman.

Contraindication

Daivonex cream & ointment is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparations. It is also contraindicated in patients with known disorders of calcium metabolism.

Acute Overdose

Topically applied Daivonex can be absorbed in sufficient amounts to produce systemic effects. Elevated serum calcium has been observed with excessive use of topical Daivonex. If elevation in serum calcium should occur, discontinue treatment until normal calcium levels are restored.

Storage Condition

Store at 15 °C -25 °C (59 °F -77 °F). Do not freeze.

Innovators Monograph

You find simplified version here Daivonex

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http://classyfire.wishartlab.com/tax_nodes/C0001553
http://classyfire.wishartlab.com/tax_nodes/C0001661
http://classyfire.wishartlab.com/tax_nodes/C0001292
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:50749
http://www.lipidmaps.org/data/LMSDRecord.php?LMID=LMST03020106
http://www.hmdb.ca/metabolites/HMDB0015567
http://www.genome.jp/dbget-bin/www_bget?drug:D01125
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5288783
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507122
https://www.chemspider.com/Chemical-Structure.4450880.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369964
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=29365
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=50749
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1200666
https://zinc.docking.org/substances/ZINC000003921872
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000292
http://www.pharmgkb.org/drug/PA448714
http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2778
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/MC9
http://www.rxlist.com/cgi/generic/calcipo.htm
https://en.wikipedia.org/wiki/Calcipotriol
*** Taking medicines without doctor's advice can cause long-term problems.
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