MedicinesFAQ

Davedax Uses, Dosage, Side Effects and more

Davedax is an antidepressant drug used in the treatment of clinical depression, panic disorder and ADD/ADHD. Its mesylate (i.e. methanesulfonate) salt is sold under tradenames including Edronax, Norebox, Prolift, Solvex, Davedax or Vestra. Davedax has two chiral centers, but it only exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine.

Davedax is a selective noradrenaline reuptake inhibitor (NaRI), the first drug of new antidepressant class. Davedax is an a-ariloxybenzyl derivative of morpholine. Davedax is primarily used to treat depression but has also been found useful in the treatment of narcolepsy and panic disorders.

Attribute Details
Trade Name Davedax
Generic Reboxetine
Reboxetine Other Names Reboxetina, Reboxetine
Type
Formula C19H23NO3
Weight Average: 313.397
Monoisotopic: 313.167793605
Protein binding

98%

Groups Approved, Experimental
Therapeutic Class
Manufacturer
Available Country
Last Updated: January 7, 2025 at 1:49 am
   

Uses

Davedax is a drug used for the acute treatment of major depression and for maintenance therapy of depression.

For the treatment of clinical depression.

Davedax is also used to associated treatment for these conditions: Major Depressive Disorder (MDD), Maintenance

How Davedax works

Davedax is a selective inhibitor of noradrenaline reuptake. It inhibits noradrenaline reuptake in vitro to a similar extent to the tricyclic antidepressant desmethylimipramine. Davedax does not affect dopamine or serotonin reuptake and it has low in vivo and in vitro affinity for adrenergic, cholinergic, histaminergic, dopaminergic and serotonergic receptors.

Toxicity

Reports of seizures (rare) have been reported

Elimination Route

Davedax is rapidly and extensively absorbed following oral administration.

Half Life

12.5 hours

Innovators Monograph

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