Dehydrocholate

Dehydrocholate Uses, Dosage, Side Effects, Food Interaction and all others data.

Dehydrocholate is a synthetic bile acid that was prepared from the oxidation of cholic acid with chromic acid . It has been used for stimulation of biliary lipid secretion. The use of dehydrocholic acid in over-the-counter products has been discontinued by Health Canada.

Following infusion of dehydrocholic acid (DHCA) in rats, the secretions of all the endogenous biliary bile acids were decreased within 30-60 minutes of infusion . Phospholipid secretion as well as cholesterol levels were also declined. The bile flow was increased after administration of dehydrocholic acid .

Trade Name Dehydrocholate
Generic Dehydrocholic acid
Dehydrocholic acid Other Names Decholin, Dehydrocholate, Dehydrocholic acid
Type
Formula C24H34O5
Weight Average: 402.531
Monoisotopic: 402.240624195
Protein binding

No pharmacokinetic data available.

Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Dehydrocholate
Dehydrocholate

Uses

No approved therapeutic indications.

Dehydrocholate is also used to associated treatment for these conditions: Dyspepsia

How Dehydrocholate works

It is proposed that dehydrocholic acid induces choleresis, which is associated with biliary lipid secretion and reduced secretion of endogenous and/or exogenous biliary components . Dehydrocholate may decrease bile phospholipid secretion due to a lack of micelle formation by dehydrocholic acid-produced bile . A study suggests that due to enhanced permeability of tight junctions in the canalicular membranes, dehydrocholic acid facilitates direct exchange between bile and plasma .

Toxicity

Oral LD50, intravenous LD50, and intramuscular LD50 in rat is 4000 mg/kg, 750 mg/kg, and 1500 mg/kg, respectively . Oral LD50, subcutaneous LD50, and intravenous LD50 in mouse is 3100 mg/kg, 1620 mg/kg, and 1492 mg/kg, respectively . There have been no reports of overdose with dehydrocholic acid.

Food Interaction

No interactions found.

Volume of Distribution

No pharmacokinetic data available.

Elimination Route

The duodenal experiment indicates that dehydrocholic acid is absorbed from the proximal small intestine .

Half Life

No pharmacokinetic data available.

Clearance

No pharmacokinetic data available.

Elimination Route

Administered dehydrocholic acid is excreted rapidly in bile as glycine- and taurine-conjugated bile acids .

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