Dencol
Dencol Uses, Dosage, Side Effects, Food Interaction and all others data.
Dencol is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever .
Choline Salicylate is the choline salt of salicylic acid, used as an analgesic, antipyretic and antirheumatic. It relieves mild to moderate pain and reduce fever and inflammation or swelling. Dencol is effective in the treatment of gout, rheumatic fever, rheumatoid arthritis and muscle injuries .
This drug is also a main ingredient in teething gels to relieve pains associated with tooth growth in the infant population . The UK government has regulated its use, due to toxicity in those under 16 years of age. Topical oral salicylate gels are no longer indicated for people younger than 16 years for pain associated with infant teething, orthodontic devices, cold sores, or mouth ulcers .
| Trade Name | Dencol |
| Generic | Choline salicylate |
| Choline salicylate Other Names | Choline salicylate |
| Type | |
| Formula | C12H19NO4 |
| Weight | Average: 241.287 Monoisotopic: 241.131408096 |
| Protein binding | Salicylic acid is highly (80-90%) protein bound . |
| Groups | Approved, Nutraceutical |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Turkey |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
The oral gel is indicated for the relief of pain and discomfort of common mouth ulcers, cold sores, denture sore spots, infant teething and mouth ulcers, and sore spots due to orthodontic devices in children .
Dencol is also used to associated treatment for these conditions: Cold Sore, Cough, Fever, Headache, Infection, Nasal Congestion, Phlegm, Sore Throat, Minor aches, Minor pain, Ulceration of the mouth
How Dencol works
Dencol relieves pain by inhibition of prostaglandin synthesis and reduces fever by acting on the hypothalamus heat-regulating center. It also inhibits the generation of impulses through the inhibition of cyclooxygenase enzyme (COX) , .
Cyclooxygenase is involved in the production of prostaglandins, in response to injury and after various other stimuli. The prostaglandins promote pain, swelling, and inflammation. The choline salicylate decreases inflammation and pain by reducing the production of these prostaglandins in the area of the mouth it is applied to .
Toxicity
LD50, oral in mouse: 2690mg/kg . Ld50, subcutaneous in mouse: 1gm/kg .
Interferes with thyroid function test .
Gastrointestinal (GI) disorders, fatigue, hypersensitivity reactions, skin eruptions, hemolytic anemia, weakness, dyspnoea; local irritation (rectally); Reye's syndrome.
Potentially Fatal: Paroxysmal bronchospasm; hepatotoxicity; renal impairment/failure; thrombocytopenia, iron-deficiency anemia, occult bleeding, leukopenia; mild chronic salicylate intoxication .
Salicylate poisoning is normally associated with plasma concentrations >350 mg/L (2.5 mmol/L). Most adult deaths due to salicylate poisoning occur in patients whose serum concentrations of salicylate are over 700 mg/L (5.1 mmol/L). Single doses of less than 100 mg/kg are very unlikely to lead to serious poisoning. Patients should be provided with supportive therapy or treatment for salicylate poisoning as necessary. This may include treatment like activated charcoal, urinary alkalinization and, in severe cases, hemodialysis .
Food Interaction
No interactions found.Volume of Distribution
0.15 L/kg (salicylate), and widely distributed throughout extracellular water and most tissues
Elimination Route
Onset: 1-2 hr after ingestion
In the oral form, choline salicylate is absorbed across the buccal mucosa. There is a need for caution not to exceed the stated dose and monitor for any signs of suggested salicylism, especially when this drug is used for infants .
In one study, it was found that this drug was more rapidly absorbed than ASA (absorption t1/2 = 0.1 vs 0.36 h) .
Half Life
The plasma half-life of salicylic acid is 2-4 hours . Up to 15 – 30 h with larger doses due to saturation of liver metabolism capacity .
Elimination Route
Both metabolites of choline salicylate, and a small amount of intact salicylic acid are excreted, primarily in the urine [L1239].
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