Desirudin
Desirudin Uses, Dosage, Side Effects, Food Interaction and all others data.
Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three disulfide bridges. Desirudin has a chemical formula of C287H440N80O110S6 with a molecular weight of 6963.52.
It is mainly indicated for the prevention of deep vein thrombosis in hip replacement surgery patients.Common side effects include: Bleeding gums, collection of blood under the skin, coughing up blood, deep, dark purple bruise and difficulty with breathing or swallowing.
Desirudin results in dose-dependent prolongation of the activated partial thromboplastin time (aPTT).
| Trade Name | Desirudin |
| Availability | Discontinued |
| Generic | Desirudin |
| Desirudin Other Names | 63-Desulfohirudin, 63-Desulfohirudin (Hirudo Medicinalis Isoform HV1), 63-Desulfohirudin (recombinant), Desirudin, Desirudin recombinant, Desirudina, Hirudin desirudin |
| Related Drugs | Xarelto, Eliquis, enoxaparin, apixaban, rivaroxaban, heparin |
| Weight | 15mg, |
| Type | Subcutaneous Powder For Injection, Subcutaneous |
| Formula | C287H440N80O110S6 |
| Protein binding | Desirudin binds specifically and directly to thrombin, forming an extremely tight, non-covalent complex with an inhibitionconstant of approximately 2.6 x 10-13 M. Thus, free or protein bound desirudin immediately binds circulating thrombin. |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Indicated as prophylaxis of deep vein thrombosis for patients undergoing hip replacement surgery.
Desirudin is also used to associated treatment for these conditions: Deep Vein Thrombosis
How Desirudin works
Desirudin is a direct, highly selective thrombin inhibitor. Reversibly binds to the active thrombin site of free and clot-associated thrombin. Inhibits fibrin formation, activation of coagulation factors V, VII, and XIII, and thrombin-induced platelet aggregation resulting in a dose-dependent prolongation of the activated partial thromboplastin time (aPTT).
Toxicity
No data available.
Food Interaction
- Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.
Desirudin Drug Interaction
Major: bivalirudin, bivalirudin, warfarin, warfarin, enoxaparin, enoxaparin, dabigatran, dabigatranUnknown: bevacizumab, bevacizumab, levetiracetam, levetiracetam, temozolomide, temozolomide, emtricitabine / tenofovir, emtricitabine / tenofovir, valacyclovir, valacyclovir, acyclovir, acyclovir
Desirudin Disease Interaction
Volume of Distribution
0.25 L/kg.
Elimination Route
Absorption is complete after subcutaneous administration. Time to peak in plasma is 1 to 3 hours.
Half Life
~2 hours.
Clearance
1.5 to 2.7 mL/min/kg.
Elimination Route
Urine (40% to 50% as unchanged drug).
Innovators Monograph
You find simplified version here Desirudin
