MedicinesFAQ

Desmethylmethadone Uses, Dosage, Side Effects and more

Desmethylmethadone is used as an opioid antitussive in combination with Oxilofrine. It is marketed in Canada by Valeant under the tradename Cophylac.

Desmethylmethadone is an opioid which suppresses coughing by central and peripheral mechanisms .

Attribute Details
Trade Name Desmethylmethadone
Generic Normethadone
Normethadone Other Names Desmethylmethadone, Isomethadone I, Normethadone
Type
Formula C20H25NO
Weight Average: 295.426
Monoisotopic: 295.193614429
Groups Approved, Illicit
Therapeutic Class
Manufacturer
Available Country
Last Updated: January 7, 2025 at 1:49 am
   

Uses

Desmethylmethadone is an opioid antitussive used to treat a cough associated with inflamed mucosa.

For use in the treatment of cough when other less potent treatments have failed .

How Desmethylmethadone works

Desmethylmethadone activates central opioid receptors in the medulla to supress the cough reflex . It also likely activates peripheral opioid receptors to inhibit signalling by irritant receptors of the airway.

Toxicity

The toxic effects of normethadone are similar to those of other opioids. It can produce respiratory depression, depression of central nervous system function, and constipation .

Food Interaction

Innovators Monograph

*** Taking medicines without doctor's advice can cause long-term problems.