Desmoteplase

Desmoteplase Uses, Dosage, Side Effects, Food Interaction and all others data.

Desmoteplase is a chemical in the saliva of vampire bats. It activates plasminogen to the serine protease, plasmin. Plasmin acts by breaking down fibrin blood clots. When a vampire bat bites its victim, it secretes an enzyme that prevents the blood from clotting. The enzyme is called DSPA (Desmodus rotundus salivary plasminogen activator) and scientists are using DSPA as stroke and heart attack medication. Desmoteplase is a recombinant form of vampire bat DSPA (Salivary plasminogen activator alpha 1).

Desmoteplase is a novel thrombolytic agent derived from vampire-bat saliva. It is genetically related to the clot buster tissue plasminogen activator (t-PA) but is more potent and demonstrates a safer toxicity profile (desmoteplase does not promote kainate- or NMDA-mediated neurotoxicity in vivo). Plasminogen activators are enzymes found in all vertebrate species investigated so far. Their physiological function is the generation of localized proteolysis in the context of tissue remodeling, wound healing and neuronal plasticity.

Trade Name Desmoteplase
Generic Desmoteplase
Desmoteplase Other Names Desmoteplase, DSPA desmoteplase, rDSPA alpha 1, Salivary plasminogen activator alpha 1, Desmodus rotundus
Type
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Desmoteplase
Desmoteplase

Uses

Investigated for use/treatment in cerebral ischemia and strokes.

How Desmoteplase works

Desmoteplase targets and destroys fibrin, the structural scaffold of blood clots.

Food Interaction

  • Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.

Innovators Monograph

You find simplified version here Desmoteplase

*** Taking medicines without doctor's advice can cause long-term problems.
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