Salivary Plasminogen Activator Alpha 1

Salivary Plasminogen Activator Alpha 1 Uses, Dosage, Side Effects, Food Interaction and all others data.

Salivary Plasminogen Activator Alpha 1 is a chemical in the saliva of vampire bats. It activates plasminogen to the serine protease, plasmin. Plasmin acts by breaking down fibrin blood clots. When a vampire bat bites its victim, it secretes an enzyme that prevents the blood from clotting. The enzyme is called DSPA (Desmodus rotundus salivary plasminogen activator) and scientists are using DSPA as stroke and heart attack medication. Salivary Plasminogen Activator Alpha 1 is a recombinant form of vampire bat DSPA (Salivary plasminogen activator alpha 1).

Salivary Plasminogen Activator Alpha 1 is a novel thrombolytic agent derived from vampire-bat saliva. It is genetically related to the clot buster tissue plasminogen activator (t-PA) but is more potent and demonstrates a safer toxicity profile (desmoteplase does not promote kainate- or NMDA-mediated neurotoxicity in vivo). Plasminogen activators are enzymes found in all vertebrate species investigated so far. Their physiological function is the generation of localized proteolysis in the context of tissue remodeling, wound healing and neuronal plasticity.

Salivary Plasminogen Activator Alpha 1
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Trade Name	Salivary Plasminogen Activator Alpha 1
Generic	Desmoteplase
Desmoteplase Other Names	Desmoteplase, DSPA desmoteplase, rDSPA alpha 1, Salivary plasminogen activator alpha 1, Desmodus rotundus
Type
Groups	Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Investigated for use/treatment in cerebral ischemia and strokes.

How Salivary Plasminogen Activator Alpha 1 works

Salivary Plasminogen Activator Alpha 1 targets and destroys fibrin, the structural scaffold of blood clots.

Food Interaction

Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.