DHA Paclitaxel
DHA Paclitaxel Uses, Dosage, Side Effects, Food Interaction and all others data.
A combination of DHA (a natural fatty acid) and paclitaxel (an anticancer drug) being studied in the treatment of cancer. It is a type of mitotic inhibitor.
| Trade Name | DHA Paclitaxel |
| Generic | Paclitaxel docosahexaenoic acid |
| Paclitaxel docosahexaenoic acid Other Names | DHA Paclitaxel, DHA-paclitaxel, Paclitaxel docosahexaenoic acid ester |
| Type | |
| Formula | C69H81NO15 |
| Weight | Average: 1164.3791 Monoisotopic: 1163.560620927 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in breast cancer, colorectal cancer, gastric cancer, kidney cancer, lung cancer, pancreatic cancer, prostate cancer, and skin cancer.
How DHA Paclitaxel works
A prodrug comprised of the naturally occurring omega-3 fatty acid docosahexaenoic acid (DHA) covalently conjugated to the anti-microtubule agent paclitaxel. Because tumor cells take up DHA, DHA-paclitaxel is delivered directly to tumor tissue, where the paclitaxel moiety binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. Paclitaxel also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). DHA-paclitaxel exhibits improved pharmacokinetic and toxicity profiles when compared to conventional paclitaxel and has demonstrated antineoplastic activity in animal models of cancer.
Innovators Monograph
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