Paclitaxel Docosahexaenoic Acid Ester

Paclitaxel Docosahexaenoic Acid Ester Uses, Dosage, Side Effects, Food Interaction and all others data.

A combination of DHA (a natural fatty acid) and paclitaxel (an anticancer drug) being studied in the treatment of cancer. It is a type of mitotic inhibitor.

Paclitaxel Docosahexaenoic Acid Ester
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Uses during Pregnancy
Uses during Breastfeeding
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Trade Name	Paclitaxel Docosahexaenoic Acid Ester
Generic	Paclitaxel docosahexaenoic acid
Paclitaxel docosahexaenoic acid Other Names	DHA Paclitaxel, DHA-paclitaxel, Paclitaxel docosahexaenoic acid ester
Type
Formula	C₆₉H₈₁NO₁₅
Weight	Average: 1164.3791 Monoisotopic: 1163.560620927
Groups	Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Investigated for use/treatment in breast cancer, colorectal cancer, gastric cancer, kidney cancer, lung cancer, pancreatic cancer, prostate cancer, and skin cancer.

How Paclitaxel Docosahexaenoic Acid Ester works

A prodrug comprised of the naturally occurring omega-3 fatty acid docosahexaenoic acid (DHA) covalently conjugated to the anti-microtubule agent paclitaxel. Because tumor cells take up DHA, DHA-paclitaxel is delivered directly to tumor tissue, where the paclitaxel moiety binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. Paclitaxel also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). DHA-paclitaxel exhibits improved pharmacokinetic and toxicity profiles when compared to conventional paclitaxel and has demonstrated antineoplastic activity in animal models of cancer.