MedicinesFAQ

Dichloracetic Acid Uses, Dosage, Side Effects and more

Dichloracetic Acid, often abbreviated DCA, is an acid analogue of acetic acid in which two of the three hydrogen atoms of the methyl group have been replaced by chlorine atoms. Salts of DCA are used as drugs since they inhibit the enzyme pyruvate dehydrogenase kinase. Early reports of its activity against brain cancer cells led patients to treat themselves with DCA, which is commercially available in non-pharmaceutical grade. A phase 1 study in 5 patients concluded that DCA was safe, but wasn't designed to establish effectiveness.

DCA was approved for use in Canada in 1989 (as a topical formulation for treatment of warts and for cauterization and removal of a wide variety of skin and tissue lesions), but was cancelled post market.

Attribute Details
Trade Name Dichloracetic Acid
Generic Dichloroacetic acid
Dichloroacetic acid Other Names Dichloracetic acid, Dichloroacetate
Type
Formula C2H2Cl2O2
Weight Average: 128.942
Monoisotopic: 127.943184722
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: January 7, 2025 at 1:49 am
   

Toxicity

ORAL (LD50): Acute: 2820 mg/kg [Rat]; DERMAL (LD50): Acute: 510 mg/kg Rabbit

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