Dici
Dici Uses, Dosage, Side Effects, Food Interaction and all others data.
Dici is a prodrug which is metabolized to rhein. It is currently approved in France for the treatment of osteoarthritis although the use of diacerein is restricted due to the side effects including severe diarrhea . Dici is under investigation for the treatment of Insulin Resistance, Diabetes Mellitus (Type 2), and Diabetes-Related Complications.
Decreases inflammation and cartilage destruction and also corrects altered osteoblast acitivity .
| Trade Name | Dici |
| Generic | Diacerein |
| Diacerein Other Names | Diacerein, Diacereína |
| Type | Capsule |
| Formula | C19H12O8 |
| Weight | Average: 368.297 Monoisotopic: 368.053217346 |
| Protein binding | 99% of rhein is bound to plasma proteins . |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | Nordic Formulations Pvt Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Dici is an slow-onset anthraquinone IL-1 inhibitor used in the treatment of degenerative joint diseases like osteoarthritis.
For the treatment of osteoarthritis affecting the hip or knee .
Dici is also used to associated treatment for these conditions: Osteoarthritis in the Hip Joint, Osteoarthritis of the Knee
How Dici works
Dici's active metabolite rhein Rhein reduces cartilage destruction by decreasing expression of matrix metalloproteinase (MMP)-1 and -3 as well as upregulating tissue inhibitor of matrix metalloproteinases which serve to reduce the activity of several MMPs . The anti-inflammatory action of rhein reduces the level of interleukin-1beta activity which plays a large role in reduction of extracellular matrix production, MMP activity, and continued inflammation . Rhein reduces abnormal osteoblast synthetic activity through an unknown mechanism .
Toxicity
Rhein Rhein has an oral LD50 of >5000mg/kg in mice. This is equivalent to a diacerein dose of >6476mg/kg.
Volume of Distribution
15-60L .
Elimination Route
Bioavailability of 50-60% . Entirely converted to the active metabolite rhein Rhein before reaching systemic circulation.
Half Life
4-10h .
Clearance
Total CL is 1.5L/h and renal CL is 0.1L/h .
Elimination Route
37% excreted in urine and 53% in feces as estimated in rats .
Innovators Monograph
You find simplified version here Dici
FAQ
What is Dici used for?
Dici is a slow-acting medicine of the class anthraquinone used to treat joint diseases such as osteoarthritis.
How safe is Dici?
Dici is safe, apart from a substantially higher risk of diarrhoea, especially with longer-term use.Dici has an acceptable safety profile, particularly in comparison with that of NSAIDs and paracetamol. The ESCEO positions Dici as a first-line pharmacological background treatment of osteoarthritis.
How does Dici work?
Dici works by blocking the actions of interleukin-1 beta, a protein involved in the inflammation and destruction of cartilage that plays a role in the development of symptoms of degenerative joint diseases such as osteoarthritis.
What are the common side effects of Dici?
Common side effects of Dici are include:
- Diarrhoea.
- Stomach discomfort and pain.
- Nausea.
- Vomiting.
- Yellowing of skin and eyes.
- Urine discoloration.
- Increase in liver enzyme levels.
- Allergic skin reaction.
Is Dici safe during pregnancy?
Dici should not be administered during pregnancy.
Is Dici safe during breastfeeding?
Dici should not be administered during lactation.
Can I drink alcohol with Dici?
Patients should be advised to limit their alcohol intake while on treatment with Dici.
Can I drive after taking Dici?
Dici may cause dizziness and drowsiness. So if you observe such symptoms, then do not drive.
When should be taken of Dici?
The recommended starting dose is 50 mg once daily with evening meal for the first 2 to 4 weeks of treatment, after which the recommended daily dose is 50 mg twice daily.
Can I take Dici on an empty stomach?
The Dici should be taken with food, one with breakfast and the other with evening meal.
How often can I take Dici?
The recommended dose is 50 mg to be taken twice daily.
How long does Dici take to work ?
Dici starts showing its action in 2-3 hours. The duration of action of Dici is 27 hours
How long can Dici be taken?
The duration of action of Dici is 27 hours.
Who should not take Dici?
Dici should not be used in any patient with liver disease or a history of liver disease, and doctors should be monitoring their patients for early signs of liver problems.
Is Dici an antibiotic?
Dici is a novel antibacterial agent; the antibacterial breakpoint could not be found in the literature or in standards.
What happen If I missed a dose of Dici?
If you forget to take a dose of Dici, make sure that you remember to take your next dose when it is due. Do not take two doses together to make up for a missed dose.
What happen if I overdose on Dici?
Never take more than the prescribed dose. Seek emergency medical treatment or contact the doctor if you suspect that you might have taken an overdose of Dici.
Can Dici causes diarrhoea?
Dici may cause diarrhoea or loose stools in the first few days of treatment. Contact your doctor if the diarrhoea does not stop within 3-4 days.
Who should not take Dici?
Avoid taking Dici if you are allergic to it. Seek medical attention if you notice any allergic reactions such as skin rash, hives (painful, itchy eruptions that sting), swelling (face, lips, tongue, etc.), breathing difficulty, etc. Dici is excreted through the kidneys.
If you have pre-existing kidney problems, this medicine may accumulate in your kidneys and further worsen your condition. Hence, this medicine is not recommended for use if you have kidney problems.
Can Dici affects my heart ?
Dici Improves Left Ventricular Remodeling and Cardiac Function by Reducing the Inflammatory Response after Myocardial Infarction.
Does Dici cause kidney damage?
Dici has shown to be safe and effective in patients with moderate to severe renal impairment, and dose adjustment is not required in these patients.
Can Dici affects my liver?
Around 0.5% of patients on Dici had some kind of liver reaction, with most cases being mild, reversible increases in serum transaminases.
