Diclofenamide
Diclofenamide Uses, Dosage, Side Effects, Food Interaction and all others data.
A carbonic anhydrase inhibitor that is used in the treatment of glaucoma.
Dichlorphenamide is an oral carbonic anhydrase inhibitor indicated for adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure. Carbonic anhydrase inhibitors reduce intraocular pressure by partially suppressing the secretion of aqueous humor (inflow).
| Trade Name | Diclofenamide |
| Generic | Diclofenamide |
| Diclofenamide Other Names | Dichlofenamide, Dichlorophenamide, Dichlorphenamide, Diclofenamida, Diclofenamide, Diclofenamidum |
| Type | |
| Formula | C6H6Cl2N2O4S2 |
| Weight | Average: 305.159 Monoisotopic: 303.914603484 |
| Protein binding | 55% |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Diclofenamide is a carbonic anhydrase inhibitor used for the management of open-angle and secondary glaucoma, as well as acute angle-closure glaucoma in delayed pre-operative setting requiring a reduction in intraocular pressure.
For adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure
Diclofenamide is also used to associated treatment for these conditions: Hypokalemic Periodic Paralysis, Increased Intra Ocular Pressure (IOP), Paralysis, Hyperkalemic Periodic
How Diclofenamide works
Carbonic anhydrase inhibitors reduce intraocular pressure by partially suppressing the secretion of aqueous humor (inflow), although the mechanism by which they do this is not fully understood. Evidence suggests that HCO3- ions are produced in the ciliary body by hydration of carbon dioxide under the influence of carbonic anhydrase and diffuse into the posterior chamber which contains more Na+ and HCO3- ions than does plasma and consequently is hypertonic. Water is then attracted to the posterior chamber by osmosis, resulting in a drop in pressure.
Food Interaction
- Increase consumption of potassium-rich foods. Diclofenamide may cause hypokalemia, therefore consuming more potassium-rich foods may help prevent hypokalemia.
Innovators Monograph
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