Digoxin-specific Antibody Fragments
Digoxin-specific Antibody Fragments Uses, Dosage, Side Effects, Food Interaction and all others data.
Digoxin Immune Fab is a sheep antibody (26-10) FAB fragment from sheep immunized with the digoxin derivative Digoxindicarboxymethylamine. It is used as an antidote for overdose of digoxin.
DigiFab binds molecules of digoxin, making them unavailable for binding at their site of action on cells in the body. The Fab fragment-digoxin complex accumulates in the blood, from which it is excreted by the kidney. The net effect is to shift the equilibrium away from binding of digoxin to its receptors in the body, thereby reversing its effects.
| Trade Name | Digoxin-specific Antibody Fragments |
| Generic | Digoxin Immune Fab (Ovine) |
| Digoxin Immune Fab (Ovine) Other Names | Digitalis antitoxin, Digoxin Immune Fab, Ovine, Digoxin-specific Antibody Fragments, Ovine digoxin immune fab |
| Type | |
| Formula | C2085H3223N553O672S16 |
| Weight | 47301.7 Da |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Digoxin-specific Antibody Fragments is an antibody binding fragment which binds digoxin molecules which is used as an antidote to digoxin overdose.
For treatment of digitoxin overdose or digitalis glycoside toxicity.
Digoxin-specific Antibody Fragments is also used to associated treatment for these conditions: Digoxin toxicity, Digoxin overdose
How Digoxin-specific Antibody Fragments works
Binds excess digoxin or digitoxin molecules circulating in the blood.
Food Interaction
No interactions found.Volume of Distribution
- 0.3 L/kg [DigiFab]
- 0.4 L/kg [Digibind]
Half Life
15-20 hrs
Elimination Route
Cumulative urinary excretion of digoxin was comparable for both products and exceeded 40% of the administered dose by 24 hours.
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