Dilamide Oral Suspension 250 mg/5 ml

Dilamide Oral Suspension 250 mg/5 ml Uses, Dosage, Side Effects, Food Interaction and all others data.

Diloxanide is a luminal amoebicide which is hydrolysed in the gut, thus releasing the free diloxanide which acts as an amoebicide. It is given alone in asymptomatic cyst passers. For patients with active amoebic infections, it can be administered with a 5-nitroimidazole e.g. metronidazole or tinidazole.

Diloxanide is a luminal amebicide, however the mechanism of action of diloxanide is unknown. Diloxanide destroys the trophozoites of E. histolytica that eventually form into cysts. The cysts are then excreted by persons infected with asymptomatic amebiasis. Diloxanide furoate is a prodrug, and is hydrolyzed in the gastrointestinal tract to produce diloxanide, the active ingredient.

Trade Name Dilamide Oral Suspension 250 mg/5 ml
Generic Diloxanide Furoate
Diloxanide Furoate Other Names Dichlofurazol, Diloxanide furoate, Diloxanidi furoas
Weight 250 mg/5 ml
Type Oral Suspension
Formula C14H11Cl2NO4
Weight Average: 328.147
Monoisotopic: 327.006513259
Groups Approved
Therapeutic Class Amoebicides
Manufacturer Pharmadesh Laboratories Ltd.
Available Country Bangladesh
Last Updated: October 19, 2023 at 6:27 am
Dilamide Oral Suspension 250 mg/5 ml
Dilamide Oral Suspension 250 mg/5 ml

Uses

Diloxanide is used for intestinal amoebiasis

How Dilamide Oral Suspension 250 mg/5 ml works

Unknown. Diloxanide may inhibit protein synthesis.

Dosage

Dilamide Oral Suspension 250 mg/5 ml dosage

Adult: The recommended dose is 500 mg 3 times/day for 10 days. May repeat course if needed.

Child: >25 kg: 20 mg/kg daily in 3 divided doses for 10 days, repeated if necessary.

Side Effects

The frequency of these side-effects is unknown flatulence, itching, urticaria, vomiting

Precaution

Caution should be exercised in pregnant and breastfeeding women. Avoid excess dosage.

Interaction

There are no known drug interactions and none well documented.

Elimination Route

Bioavailability is 90% (in diloxanide parental form), however diloxanide furoate is slowly absorbed from the gastrointestinal tract.

Half Life

3 hours

Elimination Route

Renal (90%, rapidly excreted as glucuronide metabolite). 10% is excreted in the feces as diloxanide.

Pregnancy & Breastfeeding use

Pregnancy Category- Not Classified. FDA has not yet classified the drug into a specified pregnancy category.

Contraindication

Hypersensitivity.

Innovators Monograph

You find simplified version here Dilamide Oral Suspension 250 mg/5 ml

*** Taking medicines without doctor's advice can cause long-term problems.
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