Dilor-400

Dilor-400 Uses, Dosage, Side Effects, Food Interaction and all others data.

Dilor-400 is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis.

Dilor-400, a xanthine derivative, is a bronchodilator used for relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema. Dilor-400 is a xanthine derivative with pharmacologic actions similar to theophylline and other members of this class of drugs. Its primary action is that of bronchodilation, but it also exhibits peripheral vasodilatory and other smooth muscle relaxant activity to a lesser degree.

Table Of contents

• Dilor-400
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Dilor-400
Availability	Discontinued
Generic	Dyphylline
Dyphylline Other Names	Dihydroxypropyl theopylin, Diprofilina, Diprophylline, Diprophyllinum, Dyphylline
Related Drugs	Trelegy Ellipta, amoxicillin, prednisone, doxycycline, ciprofloxacin, azithromycin, ceftriaxone, levofloxacin, Symbicort, Breo Ellipta
Type
Formula	C10H14N4O4
Weight	Average: 254.2426 Monoisotopic: 254.101504956
Protein binding	84%
Groups	Approved
Therapeutic Class
Manufacturer
Available Country	United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Dilor-400 is a theophylline derivative used to treat asthma, bronchospasm, and COPD.

For relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema.

Dilor-400 is also used to associated treatment for these conditions: Bronchial Asthma, Bronchospasm, Cheyne-Stokes Respiration

How Dilor-400 works

The bronchodilatory action of dyphylline, as with other xanthines, is thought to be mediated through competitive inhibition of phosphodiesterase with a resulting increase in cyclic AMP producing relaxation of bronchial smooth muscle as well as antagonism of adenosine receptors.

Toxicity

LD₅₀=1954 mg/kg (orally in mice)

Dilor-400 Hypertension interaction

[Moderate] Like other methylxanthines, dyphylline at high dosages may be associated with positive inotropic and chronotropic effects on the heart.

Therapy with dyphylline and products containing dyphylline should be administered cautiously in patients with severe cardiac disease, hypertension, hyperthyroidism, or recent myocardial infarction.

The relationship between plasma dyphylline levels and therapeutic as well as toxic effects has not been determined.

Dilor-400 Drug Interaction

Minor: clonazepam, clonazepamUnknown: azelastine nasal, azelastine nasal, acetaminophen / butalbital / caffeine, acetaminophen / butalbital / caffeine, cyclobenzaprine, cyclobenzaprine, fluticasone, fluticasone, ferrous sulfate, ferrous sulfate, escitalopram, escitalopram, atropine / diphenoxylate, atropine / diphenoxylate, gabapentin, gabapentin, acetaminophen, acetaminophen

Dilor-400 Disease Interaction

Major: renal dysfunction, PUDModerate: cardiotoxicity, GERD

Half Life

2 hours (range 1.8 - 2.1 hours)

Elimination Route

Dilor-400 exerts its bronchodilatory effects directly and, unlike the­ophylline, is excreted unchanged by the kidneys without being metabolized by the liver. Approximately 88% of a single oral dose can be recovered from the urine unchanged.

Innovators Monograph

You find simplified version here Dilor-400